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Topical azole antifungals (clotrimazole, ketoconazole meconazole) can be applied
every night for 2 weeks. Weekly applications of any of the topical agents for the
following few months may help prevent recurrence.
Systemic treatment is also effective and is often preferred by patients because of
convenience. Ketoconazole 200-mg daily for 10-days and as a single-dose 400-mg
treatment, have comparative results. Oral therapy does not prevent the high rate of
recurrence, unless repeated on an intermittent basis throughout the year.
3.7.6. Candidiasis
Candida infections caused by yeast-like fungi Candida albicans commonly occur in
moist, flexural sites. These fungi live on all surfaces of our bodies. Under certain
conditions, they can become so numerous that they cause infections, particularly in
warm and moist areas.
The factors associated with increased colonization rates.
Broad-spectrum antibiotics by compromising the mucocutaneous protective
bacterial flora
Depressed cell-mediated immunity either acquired or congenital
Diabetes mellitus
Systemic corticosteroid treatment
Hematological malignancies and solid tumors
Severe traumas and burns
Premature birth
Three of every four women have at least one bout of vulvovaginal candidiasis (VVC)
during their lifetime.
More than 90% of HIV positive patients experience oropharyngeal candidiasis (OPC),
and 10% have at least one episode of esophageal candidiasis.
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