Page 297 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C1.8. Tumor characteristics—Gleason score (continued)
Author Database Gleason score 1980- 1985- 1990- 1995- 2000- 2005- Statistical Notes
Year groups 1984 1989 1994 1999 2004 2010 analysis
PMID
86
Barnholtz-Sloan SEER- Tumor grade
2003 Detroit I 31.3% 14.3% NR
14575366 II 31.6% 56.2%
III 18.9% 19.3%
IV 1.7% 0.6%
Unknown 16.5% 9.6%
(1980- (1990-97)
89)
52
Schwartz SEER- Well diff. 30.2% 25.5% 12.4% P=0.001
1999 Detroit Moderately diff. 28.6% 39.4% 54.4% (proportion of
10197854 Poorly diff. 18.9% 19.3% 17.9% moderately
Undifferentiated 2.3% 1.1% <1% differentiated
Unknown 20.0% 14.7% 14.8% tumors over
(1982- (1987-91) (1992-96) time)
86)
56
Stephenson SEER- 2-4 33% 27% 18% NR
1996 Utah 5-7 30% 39% 50%
8608513 8-10 21% 18% 16%
(1984) (1989) (1993)
65
Cooperberg CaPSURE 2-4 17.3% 2.9% NR
2002 5-6 50.6% 62.8%
12131295 7 19.9% 24.2%
8-10 12.2% 10.1%
(1989-97) (1997-
2001)
4
Cooperberg CaPSURE 2-4 26.5% 7.5% 1.7% P=0.003
2003 5-6 46.4% 57.7% 63.8% (Mantel-
14610406 7 17.4% 23.4% 24.7% Haenszel test for
8-10 9.7% 11.5% 9.8% trend)
(1989-92) (1996- (1999-
99) 2002)
67
Cooperberg CaPSURE 5-6 59.5% 81.6% 96.1% NR Low-risk prostate
2004 2-4 40.5% 18.4% 3.9% cancer patients
15169800 (1989-92) (1996- (1999- only (n=1990)
98) 2001)

C-66