Page 294 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C1.8. Tumor characteristics—Gleason score

Author Database Gleason score 1980- 1985- 1990- 1995- 2000- 2005- Statistical Notes
Year groups 1984 1989 1994 1999 2004 2010 analysis
PMID
22
Perrotti SEER Well diff. 37.9 20.4 P<0.001 Additional
1998 Moderately diff. 34.9 57.6 P<0.001 information is
9720554 Poorly diff. 24.4 21.4 P<0.001 presented in
(1980- (1990-94) (comparison of Figure 1 of the
84) proportions paper (1974-
between time 1994).
periods,
separately for
each grade)
30
Jani SEER Well diff. 41% 34% 24% 12% 4% P<0.001 (chi-
2008 Moderately diff. 35% 42% 58% 69% 75% square
18845997 Poorly diff. 24% 24% 18% 19% 21% comparing
(1979- (1984-88) (1989-93) (1994- (1999- across all
83) 98) 2003) periods)
37
Jani SEER Well diff. 34% 24% 12% 4% P<0.001 Excluded
2007 Moderately diff. 41% 58% 69% 75% (chi-square test) undifferentiated
17505529 Poorly diff. 23% 18% 19% 21% RR=1.37 (1.21, tumors.
(1984-88) (1989- (1994- (1999- 1.50)
1993) 1998) 2003)
46
Polednak SEER High grade 20.6% 19.1% P<0.001 Data were
2002 [White] (1992) (1997) (chi-square for reported only for
12477140 linear trend in non-Hispanic
proportions for White and Black
the period 1992- patients.
1998)
SEER High grade 24.7% 20.6% P<0.005 Data were
[Black] (1992) (1997) (chi-square for reported only for
linear trend in non-Hispanic
proportions for White and Black
the period 1992- patients.
1998)

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