Page 470 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Year: Blinding: Inclusion: Group 2: Group 2: -85 ± 42.1 micromol/litre
1988 Not reported Indirect hyperbilirubinaemia Phototherapy + Riboflavin

Country: Randomisation: Exclusion: Riboflavin (Vitamin B 2) was given as a Mean duration of treatment:
Turkey Not reported Those who received single oral dose of 3mg/kg within 30
exchange transfusions minutes of start of phototherapy. Group 1: 45.7 ± 27.5 hours
219
ID: Evidence level: Group 2: 55.0 ± 31.1 hours
1 - Demographics:
Gender (M/F): Not reported
Mean GA: Not reported
Mean BW: 3230 ± 502 g
Age at entry to study:
61.9 ± 11.0 hours
Mean TSB: Not reported
Author: Methodology: N: Group 1: No side-effects were noted Mean decrease in TSB (24 hours) : Clofibrate groups
Ashkan M RCT 90 Phototherapy Group 1: -104 ± 14 micromol/litre were combined

Year: Blinding: Inclusion: Group 2: Group 2: -186 ± 13 micromol/litre
2007 Not reported Term babies, Phototherapy + Low-dose clofibrate Group 3: -186 ± 16 micromol/litre
Birthweight between 2500
Country: Randomisation: and 3500 g, Group 2:
Iran Computerised using TsB between 292 and Phototherapy + Moderate-dose clofibrate
sealed opaque 425 micromol/litre Mean duration of treatment:
ID: envelopes Clofibrate was administered in a single Group 1: 25.3 ± 4.4 hours
212
Exclusion: dose (either low-dose = 25 mg/kg body Group 2: 14.2 ± 1.2 hours
Evidence level: Congenital anomaly, weight or moderate dose = 50 mg/kg body
1 ++ Haemolytic disease, weight) orally in a mixture of corn oil 30 Group 3: 14.7 ± 1.5 hours
Infection, minutes before breastfeeding.
Dehydration,
G6PD deficiency,
Conjugated
hyperbilirubinaemia

Demographics:
Gender (M/F): 47/43
Mean GA: 38.8 ± 1.6 weeks
Mean BW: 2542 ± 547 g
Age at entry to study:
125 ± 45.6 hours
Mean TSB:
301 ± 23.4 micromol/litre
Author: Methodology: N: Group 1: No adverse effects noted Mean decrease in TSB:
Mohammadzadeh A RCT 60 Phototherapy Group 1: -210 ± 44 micromol/litre

Year: Blinding: Inclusion: Group 2: Group 2: -184 ± 37 micromol/litre

308