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Appendix H: Evidence tables

What are the other ways of treating hyperbilirubinaemia? Are they effective?

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Author: Methodology: N: Group 1: Mean decrease in TSB (24 hours):
Pascale J RCT 24 Phototherapy Group 1: -53 ± 13.5 micromol/litre
:
Year: Blinding: Inclusion: Group 2: Group 2: -52 ± 10.2 micromol/litre
1976 Not reported Hyperbilirubinaemia Low-irradiance Phototherapy + Riboflavin Group 3: -89 ± 18.8 micromol/litre

Country: Randomisation: Exclusion: Group 3:
USA Random numerical Not reported Phototherapy + Riboflavin
selection
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ID: Demographics:
Evidence level: Gender (M/F): 12/12 Riboflavin was given for 6 hours prior to
1 + Mean GA: Not reported phototherapy and was discontinued after
Mean BW: Not reported 24 hours of phototherapy. Riboflavin
Age at entry to study: consisted of sodium phosphate 1.5mg/kg
71.3 ± 24.1 hours every 12 hours
Mean TSB: Not reported Phototherapy irradiance was 8 –
10 microwatt/cm²
Low irradiance was Phototherapy
irradiance was 6 – 7 microwatt/cm²

Author: Methodology: N: Group 1: Mean decrease in TSB (3 hours) Subjects were
Pataki L RCT 28 Phototherapy Group 1: 32 ± 55 micromol/litre awaiting exchange
transfusion
Year: Blinding: Inclusion: Group 2: Group 2: -87 ± 40 micromol/litre
1985 Not reported ABO – Incompatible Phototherapy + Riboflavin
jaundice
Country: Randomisation: Riboflavin (Vitamin B 2) was diluted by a
Hungary Not reported Exclusion: three-fold volume of physiological saline
Not reported and a single intravenous dose of 10mg/kg
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ID: Evidence level: was given slowly.
1 - Demographics:
Gender (M/F): Not reported
Mean GA: Not reported
Mean BW: 3338 ± 425 g
Age at entry to study:
50.2 ± 27.2 hours
Mean TSB:
358 ± 71micromol/litre
Author: Methodology: N: Group 1: Mean decrease in TSB:
Yurdakok M RCT 124 Phototherapy Group 1: -55 ± 67.2 micromol/litre

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