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Appendix H: Evidence tables
Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Evidence level: anaemia Respiratory distress: 2/66
3 Bradycardia: 1/66
Demographics: Hypokalemia: 1/66
Gender (M/F): 30/25 Acute renal failure: 1/66
Mean GA: 35 ± 4 weeks Omphalitis: 1/66
Mean BW:2388 ± 973 g
Age at entry to study: Not
reported
Mean TSB:
307.8 ± 136.8 micromol/litr
e
Author: Methodology: N: Group 1: Mortality:
Wishingrad L RCT 100 Double volume exchange transfusion Group 1: 3/50
Group 2: 3/50
Year: Blinding: Inclusion: Group 2:
1965 Not reported Indirect serum Bilirubin No treatment Abnormal neurological
> 307.8 micromol/litre examination (1 – 2 years)
Country: Randomisation: No anomalies, The double volume exchange transfusion Group 1: 7/50
USA Stratified Less than 7 days old (based on an estimated blood volume of Group 2: 6/50
randomisation 75ml/kg) was carried out with type
193
ID: And sealed envelopes Exclusion: specific blood, less than 72 hours old, and
used Not reported warmed to room temperature. The
umbilical vein was cannulated with a
Evidence level: Demographics: plastic catheter and plastic disposable
1 + Gender (M/F): Unclear equipment used. 10ml aliquots were used.
Mean GA: Small amounts (0.5ml) of 10% calcium
Not reported gluconate were given after each 100ml of
Mean BW: donor blood with continuous auscultation
Not reported of the heart. All babies in exchange
Age at entry to study: Not transfusion group received penicillin and
reported streptomycin.
Mean TSB:
Not reported
Author: Methodology: N: Group 1: Mortality:due to ET
Jackson J Retrospective chart 106 Exchange transfusion 2/106 (1.9 %)
review
Year: Inclusion: Permament serious
1997 Blinding: Babies who had an exchange sequelae due to ET
None transfusion 4/106 (3.8%)
Country:
USA Randomisation: Exclusion: Serious prolonged
None None sequelae due to ET
204
ID: 5/106 (4.7%)
Evidence level: Demographics:
305
