Page 462 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Mortality:
One baby died with
6 hours of ET
Three died with 24 hours
of ET
Author: Methodology: N: Group 1: Mortality: Data from one centre
Mollison P RCT 137 Exchange transfusion Group 1: 8/62 ‘N’ used
Group 2: 21/57
Year: Blinding: Inclusion: Group 2:
1952 Not reported Haemolytic disease of the Simple transfusion
newborn, Deaths due to kernicterus
Country: Randomisation: Term babies All exchange transfusion were carried out Group 1: 6/62
UK Random numbers, with 9 hours of birth, using a concentrated Group 2: 18/57
Sealed envelopes Exclusion: suspension of Rh-negative red cells
194
ID: used Not reported (60ml/lb) Kernicterus
Group 1: 12/62
Evidence level: Demographics: Group 2: 22/57
1 + Gender (M/F): Not reported
Mean GA: Not reported
Mean BW: Not reported
Age at entry to study
Not reported
Mean TSB: Not reported
Author: Methodology: Secondary publication
194
Armitage P RCT of

Year: Blinding:
1953 Not reported

Country: Randomisation:
UK Random numbers,
Sealed envelopes
195
ID: used

Evidence level:
1 +

Author: Methodology: N: Adverse Effects/ET
Patra K Retrospective chart 55 Mortality: 1/66
review Hypotension: 5/66
Year: Inclusion: Seizures: 1/66
2004 Blinding: Babies who had an exchange Platelets
Not reported transfusion, < 50 000 microlitre/litre :
Country: Hyperbilirubinaemia 29/66
USA Randomisation: Calcium < 8mg/dl: 19/66
Not reported Exclusion: Catheter malfunction: 6/66
203
ID: Poplycythemia, Hypoglycemia: 2/66

304