Page 459 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
263 ± 82 micromol/litre
Author: Methodology: N: > 2500gms > 2500gms > 2500gms Sample was divided into
Grajwer L RCT 43 Group 1: Mortality: Mean decrease in TSB: 2 groups < 2500gms and
Double Volume Exchange Transfusion of Group 1: 0/5 Group 1: -144 ± 17 micromol/litre > 2500gms before
Year: Blinding: Inclusion: whole blood less than 5 days old Group 2: 1/8 randomisation
1976 Not reported Need for exchange Group 2: -149 ± 22 micromol/litre
transfusion Group 2: < 2500gms
Country: Randomisation: Frozen erythrocytes diluted in plasma Mortality: < 2500gms
USA Not reported Exclusion: Group 1: 1/14 Mean decrease in TSB:
Not reported < 2500gms Group 2: 3/16 Group 1: -156 ± 51 micromol/litre
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ID: Evidence level: Group 1:
1 - Demographics: Exchange transfusion of whole blood less Group 2: -177 ± 24 micromol/litre
> 2500 g than 5 days old > 2500gms
Gender (M/F): Not reported Repeat ET:
Mean GA: 39.1 ± 1.8 weeks Group 2: Group 1: 1/5
Frozen erythrocytes diluted in plasma Group 2: 1/8
Mean BW:3234 ± 494 gms
Age at entry to study < 2500gms
Not reported Exchange transfusion criteria were Repeat ET:
Mean TSB: 1/ Cord blood bilirubin > 85.5 Group 1: 4/14
328 ± 25 micromol/litre micromol/litre and rapidly increasing by Group 2: 7/16

more than 8.5 micromol/litre an hour)

< 2500 g 2/ Increase of TSB > 17.1 micromol/litre
Gender (M/F): Not reported per hour during first 24 hours if cord
blood bilirubin is unknown
Mean GA: 32.6 ± 3.2 weeks 3/ Two repeated values of
Mean BW:1670 ± 434 gms 342 micromol/litre indirect bilirubin for
babies > 2500 gms or 273.6 micromol/litre
Age at entry to study
Not reported in babies < 2500gms
4/ In sick preterm babies with asphyxia or
Mean TSB: acidosis or receiving ventilatory assistance
304 ± 48 micromol/litre ET was performed at two repeated values
of 356.5 micromol/litre

Exchange transfusion was repeated after
two repeated values of 342 micromol/litre
indirect bilirubin for babies > 2500gms
and 273.6 micromol/litre for babies
< 2500gms
Author: Methodology: N: Group 1: No jaundice related outcomes Noted increased
Locham K CCT 30 Double Volume Exchange Transfusion instances of bradycardia
and fluctuations in heart
Year: Blinding: Inclusion: Group 2: rate after calcium
2002 None Jaundice requiring exchange Double Volume Exchange Transfusion + injections. One baby
transfusion Supplementary calcium had cardiac arrest.
Country: Randomisation:
India None Exclusion:

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