Page 457 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Respiratory distress, Mean potassium 6.8 ± 1.4 micromol/litre
Secondary
hyperbilirubinaemia (due to No immunoglobulin or clotting factors
medications, polycythemia, were present.
Hemoglobin and hematocrit values were
skin hematomas or equally distributed between the two
cephalhematoma) samples.

Demographics: Exchange transfusion was performed
Gender (M/F): 15/5 through the umbilical vein in 1 hour using
a disposable exchange transfusion set in
Mean GA: 39.5 ± 1.0 weeks 10 ml portions.
Mean BW: 3305 ± 392 gms No additional calcium or human albumin
Age at entry to study given

17.9 ± 6.13 hours All babies received double phototherapy
Mean TSB: after exchange transfusion.
207 ± 45 micromol/litre
Phototherapy consisted of a double blue
light united (2 x 30 microwatt/cm²)
mounted 30 cm above and under the
mattress. Babies were nursed with
10%(120ml/kg) glucose

Phototherapy discontinued at TSB
< 205 micromol/litre on two successive
occasions.

Rebound jaundice was defined as a rise of
17 micromol/litre or more after treatment
was discontinued.

Author: Methodology: N: Group 1: Mortality: Mean decrease in TSB:
Chan G RCT 42 Double Volume Exchange Transfusion Group 1: 0/27 Group 1: -193 ± 56 micromol/litre
Group 2: 0/15
Year: Blinding: Inclusion: Group 2: Group 2: -168 ± 63 micromol/litre
1976 Not reported Need for exchange Double Volume Exchange Transfusion +
transfusion Albumin priming Rebound level:
Country: Randomisation: Group 1: 74 ± 32 micromol/litre
Canada Not reported Exclusion: Double Volume Exchange Transfusion
Not reported consisted of Acid Citrate Dextrose blood Group 2: 92 ± 56 micromol/litre
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ID: Evidence level: less than 48 hours old
1 - Demographics:
Gender (M/F): 25/17 Albumin priming consisted 1 gm/kg of
Mean GA: 36.0 ± 0.7 weeks salt-poor human albumin given
intravenously 1 hour prior to the exchange
Mean BW: 2455 ± 153 gms transfusion
Age at entry to study
Not reported
Mean TSB:

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