Page 461 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Not reported
201
ID: Evidence level:
1 - Demographics:
Gender (M/F): Not reported
Mean GA: Not reported
Mean BW: Not reported
Age at entry to study
Hrs: Not reported
Mean TSB: Not reported
Author: Methodology: N: Peripheral exchange transfusion Reported decreased :
Ahmed S Case series 198 chances of sepsis,
Brachial or radial artery was cannulated complete exchange and
Year: Blinding: Inclusion: with a 24G cannula under all aseptic more safety in peripheral
2005 None Need for exchange conditions. A good peripheral or exchange transfusion/
transfusion antecubital vein on the other side was It is also cost-effective as
Country: Randomisation: cannulated with a 22G or a 24G angiocath. only two angiocaths, two
India None Exclusion: Citrate phosphate dextrose fresh blood stop-cocks and two 10ml
None was used for the procedure & and syringes are needed
202
ID: Evidence level: phototherapy was used pre & post compared to a complete
3 Demographics: exchange. exchange set used in
Gender (M/F): 65/3 Two operators carried out the procedure umbilical route.
Mean GA: 34.5 weeks using aliquots of 5–10 ml on withdrawal;
Mean BW: Not reported and infusion. Three way stop-cocks were
Age at entry to study used on either side and arterial catheter
Not reported flushed with 0.5ml of heparin solution
Mean TSB: Not reported (5units/ml) after every 50ml.
Procedure was performed under radiant
warmer with monitoring of heart rate,
respiratory rate, body temperature and
oxygen saturation.

Author: Methodology: N: 190 Adverse effects: Mean decrease in TSB after ET: This report includes data
NICHHD Randomised :Transient bradycardia: 8 139 ± 30 micromol/litre from exchanges
controlled trial Inclusion: (4.2%) - 6 with calcium transfusions carried out
Year: Received an exchange during a RCT of
1985 Blinding: transfusion Transient cyanosis: 3 phototherpay.
None (1.6%)
Country: Exclusion:
USA Randomisation: None Transient vasospasm: 2
None (1.0%)
ID: Demographics:
129
Evidence level: Gender (M/F): Not reported Vasospasm with
++
1 Mean GA: Not reported thrombosis: 2 (1.0%)
Mean BW:
Not reported Apnea and/or bradycardia
Age at entry to study requiring treatment: 7
Not reported (3.7%)
Mean TSB: Not reported

303