Page 385 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Phototherapy discontinued at TSB
Mean TSB: 263 micromol/litre < 250 micromol/litre

Author: Holtrop P Methodology: n: 70 Group 1: ET: Mean duration
RCT Conventional phototherapy Group 1: 0/37 Group 1: Not reported
Year: Inclusion: Group 2: 0/33 Group 2: Not reported
1992 Blinding: Birthweight < 2500, Group 2:
Not reported Birthweight between 10 and Double phototherapy (Conventional Kernicterus: Mean change in TSB:
th
Country: th phototherapy Group 1: 0/37 Group 1:- 45 ± 18 micromol/litre
USA Randomisation: 90 percentile, + Fiberoptic phototherapy) Group 2: 0/33
Computer generated > 24 1 day old, Group 2: - 28 ± 20 micromol/litre
151
ID: no congenital anomalies, Mortality:
Evidence level: no Rh incompatibility Single Conventional phototherapy Group 1: 0/37
1 + TSB > 85 micromol/litre at BW consisted of either Group 2: 0/33
< 1000gms
TSB > 103 micromol/litre at 1/ if baby was in an incubator, a
standard unit (Olympic Bili-lite) with 4 Rebound jaundice:
BW 1000 - 1200gms white and 4 blue fluorescent lamps 35 Group 1: 14/37
TSB > 120 micromol/litre at cm above the baby. Group 2: 12/33
BW 1200 - 1400gms Irradiance at skin level was
TSB > 137 micromol/litre at 2
BW 1400 - 1600gms 9.2microW/cm /nm
Light range was 425 – 475
TSB > 1071 micromol/litre at
BW 1600 - 1800gms Or
TSB > 12 at BW 1800 - 2/ if baby was on a radiant warmer, 3
2200gms halogen lights on each side(Air
TSB 12 - 15 at BW 2200 - Shields7850) with an irradiance of
2
2500gms 7microW/cm /nm

Exclusion: Double phototherapy consisted of single
Not reported Conventional phototherapy as above
combined with a ‘Wallaby’ fiberoptic
Demographics: blanket measuring 10 X 35 cm. Mean
irradiance on the blanket’s surface was
2
8.2microW/cm /nm

Babies wore eye patches and wore
disposable diapers cut to allow
maximum skin exposure
Fluids were administered on clinician
advice
Author: Nuntnarumit Methodology: n: 51 Group 1: ET: Mean duration
P RCT Single Conventional phototherapy Group 1: 0/27 Group 1: 43.7 ± 17.5 hours
Inclusion: Group 2: 0/24
Year: 2002 Blinding: BW > 2500gms Group 2: Group 2: 34.9 ± 12.6 hours
Not reported GA > 37 weeks Double Conventional phototherapy Rebound jaundice:
Country: Thailand TSB ≥ 205 micromol/litre at 24– Group 1: 1/27 Mean change in TSB:
Randomisation: 48 hours Single Conventional phototherapy Group 2: 0/24 Group 1: -98 ± 46 micromol/litre
ID: Not reported TSB ≥ 256 micromol/litre at 49– consisted of 3 daylights and 2 blue
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