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Cell Signalling Biology Michael J. Berridge Module 2 Cell Signalling Pathways 2 20

Module 2: Table continued
Monomeric G protein, GEF or GAP Comments
Rab28
Rab29
Rab30 Located on Golgi
Rab31 Located on early endosomes
Rab32 Located on early melanosmes and mitochondria
Rab33A ER-to-Golgi trafficking
Rab33B
Rab34 Functions in macropinocytosis
Rab35 Located on recycling endosomes and functions in cytokinesis and formation of the
immunological synapse
Rab36
Rab37 Located on secretory granules and functions in mast cell degranulation
Rab38 Functions in formation of melanosomes
Rab39 Located on the Golgi
Rab40A
Rab40B
Rab40C
Rab41
Rab42
Rab43 ER-to-Golgi trafficking
Rab44
Arf family There are six ADP-ribosylation factors that function in actin remodelling and membrane
trafficking (Module 2: Figure PLD signalling)
Class I Operate mainly at the Golgi
Arf1
Arf2
Arf3
Class II Operate mainly at the Golgi
Arf4
Afr5
Class III
Arf6 Operates mainly at the plasma membrane. It functions in endocytosis of AMPA receptors
at synaptic endings (Module 10: Figure Ca 2 + -induced synaptic plasticity)
Arf-like (ARL) A small GTPase that interacts with golgins
Ran A small GTPase that functions in nucleocytoplasmic transport
Guanine nucleotide-exchange factors (GEFs)
RasGEFs
SoS1 Son-of-sevenless-1
SoS2 Son-of-sevenless-2
RasGRF1 Expressed in brain, particularly hippocampus
RasGRF2
RasGRF3 Expressed in brain
RasGRP1 Expressed in T cells
RasGRP2 Expressed in neutrophils and platelets
RasGRP3 Expressed in B cells
RasGRP4 Expressed in mast cells
Rho family GEFs
The Dbl family The 69 family members have a Dbl homology domain (DH)
Dbl Diffuse Bcelllymphoma
Dbs Dbl’s big sister
Ect2 Epithelial-cell transforming gene-2 that functions in cytokinesis (Module 9: Figure
cytokinesis)
Ephexin Functions in growth cone collapse mediated by EphA receptors (Module 1: Eph receptor
signalling)
DOCK180 Downstream of Crk-180 homologue is a Rac GEF (Module 2: Figure Arf signalling), which
functions in focal adhesion integrin signalling (Module 6: Figure integrin signalling)
Fgd1 Facial genital dysplasia
ITSN-L Intersectin-long controls Cdc42 activity during EphB receptor signalling (Module 1: Eph
receptor signalling)
Kalirin Functions to activate Rac during the action of Eph receptors on dendritic spine
morphogenesis (Module 1: Eph receptor signalling)
LARG Leukaemia-associated RhoGEF
NET1 Neuroepithelioma transforming gene 1
p115-RhoGEF Links G protein-coupled receptors to Rho
PDZ-RhoGEF Links G protein-coupled receptors to Rho
P-Rex1 PtdIns3,4,5P 3 -dependent Rac exchanger 1
α-Pix PAK-interacting exchange factor α
β-Pix PAK-interacting exchange factor β
Tiam1 T cell lymphoma invasion and metastasis-1
Tiam2 T cell lymphoma invasion and metastasis-2
Trio
Vav1
Vav2
Vav3
RAB GEFs See Module 2: Figure Rab signalling
Rabex-5 A GEF for Rab 5 (Module 4: Figure endosome vesicle fusion)
Rabin3
TRAPP1 A GEF for Rab1 (Module 4: Figure COPII-coated vesicles)

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