Page 76 - AIDSBK23C

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Criteria for HIV Infection

Children aged 18 months to <13 years are categorized as HIV infected for surveillance
purposes if at least one of laboratory criteria or the other criterion is met.

Laboratory Criteria

Positive result from a screening test for HIV antibody (e.g., reactive EIA), confirmed by a
positive result from a supplemental test for HIV antibody (e.g., Western blot or indirect
immunofluorescence assay).

OR

Positive result or a detectable quantity by any of the following HIV virologic (non-
antibody) tests: &-- HIV nucleic acid (DNA or RNA) detection (e.g., PCR) &-- HIV p24
antigen test, including neutralization assay &-- HIV isolation (viral culture)

Other Criterion (for Cases that Do Not Meet Laboratory Criteria)

HIV infection diagnosed by a physician or qualified medical-care provider based on the
laboratory criteria and documented in a medical record. Oral reports of prior laboratory
test results are not acceptable.

Criteria for AIDS

Children aged 18 months to <13 years are categorized for surveillance purposes as having
AIDS if the criteria for HIV infection are met and at least one of the AIDS-defining
conditions has been documented (see below).

The 2008 surveillance case definition for AIDS retains the 24 clinical conditions in the AIDS
surveillance case definition published in 1987 and revised in 1994 for children aged <13 years
(see below). Because the 2008 definition requires that all AIDS diagnoses have laboratory-
confirmed evidence of HIV infection, the presence of any AIDS-defining condition listed below
indicates a surveillance diagnosis of AIDS.

Clinical Categories for Staging of HIV Infection in the 1993 Revised Definition [392]

CATEGORY A: Conditions listed in Categories B and C must not have occurred. A person is
classified in Category A with one or more of the following conditions listed below with
documented HIV infection:

* Asymptomatic HIV infection;
* Persistent generalized lymphadenopathy;
* Acute (primary) HIV infection with accompanying illness or a history of acute HIV
infection.