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One positive HIV virologic test followed by at least two negative tests from separate
specimens, one of which is a virologic test from a specimen obtained at age >8 weeks or
an HIV antibody test from a specimen obtained at age >6 months.

AND

No other laboratory or clinical evidence of HIV infection (i.e., no subsequent positive
results from virologic tests if tests were performed, and no AIDS-defining condition for
which no other underlying condition indicative of immunosuppression exists).

Other Criteria (for Cases that Do Not Meet Laboratory Criteria for Uninfected with
HIV, Definitive or Presumptive)

Determination of uninfected with HIV by a physician or qualified medical-care provider
based on the laboratory criteria and who has noted the HIV diagnostic test results in the
medical record. Oral reports of prior laboratory test results are not acceptable.

AND

No other laboratory or clinical evidence of HIV infection (i.e., no positive results from
virologic tests [if tests were performed] and no AIDS-defining condition for which no
other underlying condition indicative of immunosuppression exists.

Criteria for Indeterminate HIV Infection

A child aged <18 months born to an HIV-infected mother is categorized as having
perinatal exposure with an indeterminate HIV infection status if the criteria for infected
with HIV and uninfected with HIV are not met.

The exclusion of HIV infection (definitive or presumptive) for surveillance purposes does not
mean that clinical HIV infection can be ruled out. These categories are used for surveillance
classification purposes and should not be used to guide clinical practice. A child with perinatal
HIV exposure should continue to be monitored clinically according to nationally accepted
treatment and care guidelines 1) monitor for potential complications of exposure to antiretroviral
medications during the perinatal period and 2) confirm the absence of HIV infection with repeat
clinical and laboratory evaluations.

2008 Surveillance Case Definitions for HIV Infection and AIDS Among Children Aged 18
Months to <13 Years

The 2008 laboratory criteria for reportable HIV infection among persons aged 18 months
to <13 years exclude confirmation of HIV infection through the diagnosis of AIDS-
defining conditions alone. Laboratory-confirmed evidence of HIV infection is now
required for all reported cases of HIV infection among children aged 18 months to <13
years.