Page 73 - AIDSBK23C

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clinical HIV infection can be ruled out. For the purposes of calculating the exact timing
of tests (e.g., when a specimen was obtained for laboratory testing) based on the
surveillance case definition, 1 month corresponds to 30 days.

Criteria for Definitive or Presumptive HIV Infection

A child aged <18 months is categorized for surveillance purposes as definitively or
presumptively HIV infected if born to an HIV-infected mother and if the laboratory
criterion or at least one of the other criteria is met.

Laboratory Criterion for Definitive HIV Infection

A child aged <18 months is categorized for surveillance purposes as definitively HIV
infected if born to an HIV-infected mother and the following laboratory criterion is met.

Positive results on two separate specimens (not including cord blood) from one or more
of the following HIV virologic (non-antibody) tests: &-- HIV nucleic acid (DNA or RNA)
detection &-- HIV p24 antigen test, including neutralization assay, for a child aged >1
month &-- HIV isolation (viral culture)

Laboratory Criterion for Presumptive HIV Infection

A child aged <18 months is categorized for surveillance purposes as presumptively HIV
infected if 1) born to an HIV-infected mother, 2) the criterion for definitively HIV
infected is not met, and 3) the following laboratory criterion is met.

Positive results on one specimen (not including cord blood) from the listed HIV virologic
tests (HIV nucleic acid detection test; HIV p24 antigen test, including neutralization
assay, for a child aged >1 month; or HIV isolation [viral culture] for definitively HIV
infected) and no subsequent negative results from HIV virologic or HIV antibody tests.

Other Criteria (for Cases that Do Not Meet Laboratory Criteria for Definitive or
Presumptive HIV Infection)

HIV infection diagnosed by a physician or qualified medical-care provider based on the
laboratory criteria and documented in a medical record. Oral reports of prior laboratory
test results are not acceptable.

OR

When test results regarding HIV infection status are not available, documentation of a
condition that meets the criteria in the 1987 pediatric surveillance case definition for
AIDS.