Page 68 - Noninvasive Diagnostic Techniques for the Detection of Skin Cancers
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Table D-3. RCTs identified in the present technical brief (continued)
 First Author   Study   Comparisons   Setting   Population (N)   Type of Outcome,   Outcome,
 UI   Objective      Mean age, yrs    Followup duration               Adverse events
 Country      Males (%)
 year            Race
             Cancer type
 59
 Zalaudek I    To determine the   Skin exam and   Pigmented   1359 patients   Process outcomes   Outcome: Median time
 18427045   time required to   dermoscopy vs. skin   lesion clinic   39.5 years   Followup duration: NA   required for complete skin
 2008   complete skin   exam alone   (dermatology)   45.9% male   examination
 Austria   examination with or   No data on race                Adverse events: not
 without   Any malignancy                                       reported
 dermoscopy
 Photodynamic diagnosis
 Ericson MB 144    To evaluate   4 groups with varying   dermatologist   40 patients   Other outcomes   Outcomes:
 12633984   tolerance threshold   ALA application time,   Age: nd   Followup duration: NA   Ratio of fluorescence
 2003   of photo-diagnosis   from 1 to 4 hrs   No data on % male   intensity between ALA
 Sweden   by evaluating ratio   No data on race                 treated tumor tissue and
 of fluorescence   Basal cell carcinoma                         normal skin
 intensity between                                              Fluorescence intensity
 ALA treated tumor                                              variation in ALA-treated
 tissue and normal                                              normal skin Adverse
 skin                                                           events: not reported
 ALA = 5-aminolevulinic acid, GPs = general practitioners, nd = no data, NPV = negative predictive value, PCPs = primary care physicians, PPV = positive predictive value;
 Sn = sensitivity; Sp =specificity.



































 D-5
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