Page 67 - Noninvasive Diagnostic Techniques for the Detection of Skin Cancers

Table D-3. RCTs identified in the present technical brief (continued)
First Author Study Comparisons Setting Population (N) Type of Outcome, Outcome,
UI Objective Mean age, yrs Followup duration Adverse events
Country Males (%)
year Race
Cancer type
59
Zalaudek I To determine the Skin exam and Pigmented 1359 patients Process outcomes Outcome: Median time
18427045 time required to dermoscopy vs. skin lesion clinic 39.5 years Followup duration: NA required for complete skin
2008 complete skin exam alone (dermatology) 45.9% male examination
Austria examination with or No data on race Adverse events: not
without Any malignancy reported
dermoscopy
Photodynamic diagnosis
Ericson MB 144 To evaluate 4 groups with varying dermatologist 40 patients Other outcomes Outcomes:
12633984 tolerance threshold ALA application time, Age: nd Followup duration: NA Ratio of fluorescence
2003 of photo-diagnosis from 1 to 4 hrs No data on % male intensity between ALA
Sweden by evaluating ratio No data on race treated tumor tissue and
of fluorescence Basal cell carcinoma normal skin
intensity between Fluorescence intensity
ALA treated tumor variation in ALA-treated
tissue and normal normal skin Adverse
skin events: not reported
ALA = 5-aminolevulinic acid, GPs = general practitioners, nd = no data, NPV = negative predictive value, PCPs = primary care physicians, PPV = positive predictive value;
Sn = sensitivity; Sp =specificity.

D-5