Page 411 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C3.1 Studies on offer, acceptance, and adherence of active surveillance (continued)
Factors examined Author Study approach AS/WW definitions Findings Issues
Year
PMID
Patient factors Anandadas 195 Prospective, multicenter study of ”AS” (not explicitly • 61/768 (8%) chose AS • Incomplete analysis of
affecting 2011 768 men with low-risk T1/T2 cancer provided) • AS was more frequently reasons for choosing AS.
treatment 21083643 who were referred to centers that chosen over time (2000: 0%; Most of those who
choice offered 4 treatment options (RP, 2006 ~20%) selected “Other” chose
RT, brachytherapy, or AS). • Reasons for choosing AS: AS, but the other reasons
Reasons for selecting treatment o More convenient for lifestyle are unexplained.
were recorded. 16% (compared to all 4 • It was not explicitly
821 men from 7 different uro- treatments: 17%) stated who provided
oncology centers in UK were o Fear of side effects 11% reason for treatment
enrolled (all were initially referred (compared to all 4 choice, though implicitly
for active treatment for early treatments: 9%) the patient himself.
prostate cancer); 53 were recruited o Fear of other options 8%
before brachytherapy was offered, (compared to all 4
they therefore were excluded from treatments: 12%)
the analysis o Combination of reasons
16% (compared to all 4
treatments: 15%)
o Other 23% (including “didn’t
want active or invasive
treatment”) (compared to all
4 treatments: 6%)
o Unknown 25% (compared
to all 4 treatments: 17%)
Patient factors Xu 196 Patients with newly dx’d localized WW (not explicitly • “For most men, both black • Only 2 patients with
affecting 2011 disease were recruited from 3 provided) and white, treatment decision WW
treatment 21830629 urology offices and 1 radiation making occurred within an
choice oncology office in Detroit and also emotional context of fear and
through flyers in hospitals and uncertainty and without
doctors’ offices; sampling aim was systematic use of information.”
to maximize a broad range of • Reasons why WW chosen
experiences, no problem recruiting (n=2):
men who chose RP or RT, had o Maintain current QoL
difficulty recruiting men who chose o Cancer small or slow-
WW; semistructured interview of 21 growing, may never cause
men with localized cancer <75 y; problems; “If it’s not bothering
attempted to select a diverse me, why mess with it”
sample of men based on race, age, o Will be able to act if cancer
social class, and income; easily progresses
recruited patients who chose o God will take care of it

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