Page 390 - 20dynamics of cancer

SUBJECT INDEX 375

renewal, 77, 261–63, 265 melanocytes, 263
See also skin renewal, 262–63, 292–94
epigenetic change, 191, 193, 213, heart disease, 204, 205, 207
220, 306 hematopoiesis, 255, 265
DNA methylation, 45–49, 71, 79– heritability, see genetic predisposi-
80, 199–200, 288–94, 297–300, tion
304 heterogeneity and incidence, 175–78,
histone modification, 71, 80, 286, 310
304 developmental, 272–80
epithelial tissue environmental, 129–35
cancer incidence, 252–53 genetic, continuous, 129–35
See also colorectal epithelium, genetic, discrete, 120–29
epidermis histones, see epigenetic change
esophageal cancer, 29–32, 170, 300,
303–4, 307, 321, 322, 331 incidence and acceleration curves,
evolutionary forces, see population plots of
genetics bladder, 317, 318, 329
bone, 24, 25
field cancerization, see mosaicism brain, 323, 324, 332
fitting models breast, 218, 315, 316
parameters, instability of esti- cervix, 325, 326
mates, 88, 146, 237 colorectum, 91, 217, 226, 317,
parameters, too many, 87 318, 328
esophagus, 321, 322, 331
gatekeeper genes, 71 Hodgkin’s lymphoma, 323, 324,
genetic predisposition, 25–29, 143– 333
64, 213–50 kidney, 321, 322, 332
common versus rare variants, larynx, 321, 322, 331
243–50 leukemia, 319, 320, 330
and incidence, 214–33 liver, 24, 25, 325, 326, 333
Mendelian variants, 26, 65–68, lung, 30, 169, 182, 183, 315, 316,
70, 89, 144–54, 161, 162, 217, 328
227–29, 232, 238–42, 291 melanoma, 319, 320, 330
natural selection and variation, myeloma, 323, 324, 332
234–42 neuroblastoma, 24
polygenic (quantitative) variation, non-Hodgkin’s lymphoma, 319,
129–35, 160–64, 228, 243–50 320, 330
genetic variation, see genetic predis- oral-pharyngeal, 317, 318, 329
position ovary, 321, 322
germline mutations, see genetic pancreas, 317, 318
predisposition prostate, 315, 316
glomuvenous malformations, 306–7 retinoblastoma, 24, 25, 27, 145,
See also mosaicism 149, 151
Gompertz model, 136–39 stomach, 319, 320, 331
testis, 24, 25
hair follicle thyroid, 323, 324, 333
bulge stem cells, 262, 292–94 Wilms’ tumor, 24, 25