Page 389 - 20dynamics of cancer

374 SUBJECT INDEX

See also design, fitting models, 161, 217, 239, 291
sporadic versus inherited cases hereditary nonpolyposis (HNPCC),
cell cycle 44–45, 47, 48, 240
accelerators, 52 histology, 40, 46–49
checkpoints, 52, 70, 113, 199 incidence and acceleration, 26, 66,
regulators, 247, 248 76, 89–91, 150–54, 216, 217,
cell death, see apoptosis 224, 226, 277, 314, 317, 318,
cell division, see mitogenesis 328
cell lineages methylation, role of, 45–48
coalescence, 55, 57, 242, 279, 285, See also microsatellite instability,
288, 289, 291, 295, 296, 302 mismatch repair
diversity and age, 287–95 colorectal epithelium
linear versus branching, 76–78, crypt and tissue renewal, 39–41,
255, 264, 265, 272–80, 283–85, 46–48, 55, 100, 256–61, 269,
290 289–92, 302
mutation accumulation, 37, 55–58, comparative predictions, see causal-
65, 70, 71, 73, 74, 76–78, 80, ity, how to study
207, 213, 253, 255, 268, 272–80,
286 death, see mortality
phylogeny, 55–58, 286–308 design, revealed by failure, 1–2, 203,
synergism between, 57, 71 208, 250
See also clonal expansion, mo- development, mutations during
saicism, stem-transit architec- and cancer risk, 272–80, 305–8
ture See also mosaicism
cell signaling, 42, 50–55, 181, 192, DNA repair
265 inherited polymorphism, 48, 129,
hormone, 35, 298, 299 161, 224–27, 229–31, 233, 240,
childhood cancer, 23–25 241, 244–50
See also mitogenesis and cancer mismatch repair (MMR), 28, 43,
risk 48, 155–60, 199, 224–27, 240,
chromosomal instability, 37, 43, 45, 244, 294–95, 302
51, 53, 70, 72, 78, 80, 200, 303 nucleotide excision repair (NER),
aneuploidy, 40, 48 200, 248–49
clonal expansion, 74–79, 109–13, role in cancer progression, 28,
178–81, 197, 198, 200, 269, 287, 45–47, 49, 51, 70, 72, 155–60,
304, 307–8 199–200, 233, 246–50, 268, 307
clonal succession, 290–92, 294–97, DNA replication, strand segregation,
302–4 see stem cells
colorectal cancer Druckrey relation, see carcinogens
adenoma-carinoma sequence, 39–
49 endometrial cancer
alternative pathways, 43–49 menopause, 299
APC, 26, 40–42, 44, 46–49, 89, obesity, 299
150, 152, 153, 160, 216, 217, England, cancer incidence in, 314–33
227, 239, 244, 291–92, 302 epidermis
familial adenomatous polyposis basal membrane, 54, 265
(FAP), 26, 66, 150, 152, 154, compartments, 77, 261–63