Page 445 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Is it beneficial to give additional fluids (cup feeds, fluids) during treatment with phototherapy?

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Author: Methodology: N: Group 1: Mean decrease in TsB:
Tontisirin K RCT 25 Formula feed – Enfamil (Energy = 20 Group 1: -97 ± 41 micromol/litre
kcal/oz, contains 1.5 g/dl protein, 3.7 g/dl
Year: Blinding: Inclusion: fat, 7 g/dl carbohydrate, mineral 0.34 g/dl, Group 2: -92 ± 46 micromol/litre
1989 Not reported Hyperbilirubinaemia TSB water 87.4 g/dl)
≥ 256.5 micromol/litre Weight gain/loss:
Country: Randomisation: Group 2: Group 1: 33 ± 65 gms
Thailand Not reported Exclusion: Lactose-free Formula feed – Enfamil
Not reported ProSobee(Energy = 20 kcal/oz, contains Group 2: -7 ± 55 gms
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ID: Evidence level: 2 g/dl protein, 3.6 g/dl fat, 6.6 g/dl
1 - Demographics: carbohydrate, mineral 0.3 g/dl, water
Gender (M/F): Not reported 87.4 g/dl)
Mean GA: Not reported
Mean BW: 3185 ± 288 gms Babies were fed ad libitum with formula
Age at entry to study: (3 ounces) 8 times/day.
95 ± 17.7 hours
Mean TSB: Not reported
Author: Methodology: N: Group 1: Exchange Transfusions Mean decrease in TsB (24 hours):
Mehta S RCT 74 Phototherapy + Usual feeds Group 1: 20/37 Group 1: -69 ± 28 micromol/litre
Group 2: 6/37 n = 17
Year: Blinding: Inclusion: Group 2:
2005 Not reported Hyperbilirubinaemia Phototherapy + Usual Feeds + Extra fluids Group 2: -95 ± 22 micromol/litre
TsB > 308 micromol/litre n = 31
Country: Randomisation: Extra fluids consisted of IV fluid
India Stratified block Exclusion: supplementation with N/5 saline in 5% Mean duration of treatment:
randomisation (based TsB > 427 micromol/litre, dextrose for a period of 8 hours before Group 1: 73 ± 31 hours
ID: on TsB levels) using Kernicterus, phototherapy. After babies were offered
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sealed opaque Evidence of hemolysis, 30mL/kg/day of extra oral feeds Group 2: 52 ± 18 hours
envelopes Signs of dehydration, (expressed breast milk or formula) until
Major congenital phototherapy discontinued
Evidence level: malformations,
1 ++ Babies on IV fluids Phototherapy was discontinued when two
TsB values obtain 12 hours apart were
Demographics: < 256 micromol/litre
Gender (M/F): 52/22
Mean GA: 37.6 ± 0.9 weeks Exchange transfusion was done if at
4 hours into the study TsB increased by
Mean BW: 2936 ± 473 gms > 34 micromol/litre or if at 8 hours TsB
Age at entry to study remained > 342 micromol/litre
130 ± 31 hours
Mean TSB:
350 ± 31micromol/litre

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