Page 446 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Author: Methodology: N: Group 1: Exchange Transfusions Mean decrease in TsB (4 hours):
Boo N RCT 54 Phototherapy + Enteral feeds alone Group 1: 5/27 Group 1: -37 ± 44 micromol/litre
Group 2: 8/27
Year: Blinding: Inclusion: Group 2: Group 2: -43 ± 37 micromol/litre
2002 Not reported TsB > 300 micromol/litre Phototherapy + 50 % Enteral feeds + 50 % Mortality
with conjugated bilirubin Intravenous feeds Group 1: 0/27
Country: Randomisation: <15% of TsB Group 2: 0/27
Malaysia Stratified All babies received a daily maintenance
randomisation (type Exclusion: fluid level of 90 mL/kg on day 2, 1290
175
ID: of feed, hydration Sick babies, mL/kg on day 3 and 150 mL/kg from day
status, and TsB Major congenital 4 onwards.
levels) using sealed malformations, They were also given an additional 10% of
envelopes Conjugated their respective total daily fluid
hyperbilirubinaemia, requirement to compensate for the fluid
Evidence level: prolonged jaundice loss.
1 +
Enteral feeds group
Demographics: Formula-fed babies were given 8 divided
Gender (M/F): 28/26 feeds at 3 hour intervals. Breastfed babies
Mean GA: 39.4 ± 0.9 weeks were breastfed on demand. In addition
they were given half of the calculated
Mean BW: 3075 ± 429 gms volume of formula feeds given to the
Age at entry to study: formula-fed babies.
139 ± 47 hours Enteral + Intravenous group
Mean TSB: Formula-fed babies were given half of
377 ± 66 micromol/litre their 24hour fluid requirement at eight
divided feeds at 3hour intervals. The
remaining half of their daily fluid
requirement was given as continuous
intravenous1/5 normal saline and 5%
dextrose infusion via a peripheral vein
over 24 hours. Breastfed babies were
breastfed on demand. Half of their daily
fluid requirement was given as continuous
intravenous1/5 normal saline and 5%
dextrose infusion via a peripheral vein
over 24 hours.
Author: Martinez J Methodology: N: 125 Group 1: ET: Mean decrease in TsB (48 hours): Only data from groups 3
RCT Continue breastfeeding Group 1: 0/25 Group 3: -77 ± 41 micromol/litre and 4 used
Year: 1993 Inclusion: Group 2: 0/26
Blinding: TSB > 291micromol/litre Group 2: Group 3: 0/38 Group 4: -65 ± 34 micromol/litre
Country: Argentina Not reported Discontinue breastfeeding, substitute Group 4: 0/36
Exclusion: formula feeds
ID: Randomisation: Congenital anomalies Treatment failure:
133
Computer-generated Neonatal complications Group 3: Group 1: 6/25
Birthweight below 10 Discontinue breastfeeding, substitute Group 2: 5/26
th
Evidence level: formula feeds, add Conventional Group 3: 1/38

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