Page 358 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Evidence Table – Assessment Tests
TSB >400 micromol/litre / or Exchange Transfusion

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Author: Nkrumah F Study type: Diagnosis: Jaundice Mean bilirubin levels Small study
Case series Criteria: TSB ≥ 342 micromol/litre TSB: 551 ± 182 micromol/litre
Year: 1973 Setting: Hospital/Paediatric outpatient
Evidence level: 3
Country: Ghana Sample Size: 35 Incidence of ABO incompatibility: 14/35 (40%)

Mean GA: Not reported Rh incompatibility: 1/35 (2.9%)
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Ref ID: Mean BW: Not reported
Gender M/F: 26/9
Ethnicity: Not reported Incidence of G6PD deficiency: 13/35 (37.1%)
Breastfeeding: Not reported Incidence of sepsis: Not reported
Onset of Jaundice: Day 0 - 8
Duration of jaundice: Not reported Idiopathic: 10/35 (28.6%)

Exclusion: None
Kernicterus
Incidence of ABO incompatibility: 6/17 (35.3%)

Rh incompatibility: 1/17 (5.9%)

Incidence of G6PD deficiency: 8/17 (47.0%)

Incidence of sepsis: Not reported

Idiopathic: 3/17 (17.6%)

Author: Manning D Study type: Diagnosis: Jaundice Mean bilirubin levels
Survey Criteria: TSB ≥ 513 micromol/litre TSB: 581 micromol/litre (510–802)
Year: 2007 Setting: Not reported
Evidence level: 3 ABO incompatibility: 33/106 (31.1%)
Country: UK & Republic Sample Size: 106
of Ireland Mean GA: 38.2 ± 1.7 weeks Rh incompatibility:6/106 (5.7%)

Ref ID: Mean BW: 3170 ± 480 gms G6PD deficiency: 5/106 (4.7%)
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Gender M/F: 64/42
Ethnicity: White 52 (48.1%), Asian 18 (16.7%), Black 11 Infection: 4/106 (3.8%)
(10.1%), Mixed 11 (10.1%)
Breastfeeding: 87 (80.5%) Idiopathic: 29/106 (27.3%)
Onset of Jaundice: Not reported
Kernicterus Cases (n = 14)
Exclusion: None ABO incompatibility: 3/14 (21.4%)

Rh incompatibility: 1/14 (7.1%)

G6PD deficiency: 3/14 (21.4%)

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