Page 286 - 16Neonatal Jaundice_compressed
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Neonatal jaundice


              Bibliographic details   Study type &   Patient characteristics   Test, Reference Standard,   Results                 Reviewers Comments
                                Evidence level                             Threshold for a positive test
                                                Gender: Males = 50%                                 SD = Not reported

                                                Prevalence of TSB >                                 Diagnostic accuracy of TcB (threshold value
                                                250 micromol/litre = 55/300 (18.3%)                 > 195 micromol/litre) for detecting TSB >
                                                                                                    250 micromol/litre
                                                Exclusion: babies who had previously
                                                received phototherapy                               Sensitivity: 50/55 (90.9%)
                                                                                                    Specificity: 162/245 (66.1%)
                                                                                                    PPV: 50/133 (37.6%)
                                                                                                    NPV: 162/167 (97%)

              Briscoe L;        Study Type:     Babies > 34 weeks who were having   TcB reading using Minolta JM-102   Correlation of JM-102 with lab TSB levels   Unselected population
                                Diagnostic study   blood taken for any reason, mostly   at the forehead   (Pearson correlation coefficient, n = 303)   Test & Reference test described
              Year: 2002                        done for clinical jaundice.   (mean of 3 readings used for                         in detail
                                Evidence Level: II                         analysis)                r = 0.76, P < 0.0001           Test and reference test carried
              Country:                          n = 303                                                                            out within one hour
              UK                                median BW 3267 g - range 1800–  Reference standard: Laboratory   Diagnostic accuracy of JM-102 for detecting   Blinding – not specified
                                                5008                       TSB levels measured concurrently   TSB > 249 micromol/litre (n = 303)   Data not extractable for
              46                                median GA 39 weeks - range 34–42                                                   calculating values of TP, FP,
                                                median age at presentation: 3 – range   For diagnostic accuracy:   Area under ROC = 0.89   TN & FN
                                                0 to 13 days               Area under ROC curve calculated
                                                Gender: Not reported       for detecting TSB        Predictive accuracy of JM-102 value 19.9
                                                                           > 249 micromol/litre     (highest accuracy from ROC curve)
                                                Ethnicity
                                                White: 94.7%                                        Sensitivity: 86% (81–89%)
                                                                                                    Specificity: 78% (73–83%)
                                                                                                    PPV: Not reported
                                                Prevalence of TSB >                                 NPV: Not reported
                                                300 micromol/litre = 3.3% (10/303)

                                                Exclusion: babies who had previously                In this study a reading of > 18 reflectance
                                                                                                    units was taken as an indicator for serum
                                                received phototherapy                               bilirubin, resulting in a reduction of 34% in
                                                                                                    the number of blood samples taken.

              Bhutani VK;       Study Type:     All babies born from 01 January 1990   Incremental hospital systems   Incidence of adverse outcomes for term and   Non-comparative observational
                                Observational study   to 31 December 2000 who were   approach in the management of   near-term infants in the well-baby nursery   study
              Year: 2006                        discharged from the well-baby   neonatal hyperbilirubinaemia   Hospital-based intensive phototherapy   Time periods of different
                                Evidence Level: III   nursery of a tertiary hospital as term   studied with different clinical   Phase 1: 3.6%   clinical approaches
              Country: USA                      and near-term healthy babies.   approaches at different phases:   Phase 2: 4.5%    overlapping. Confounding
                                                                           Phase 1:                 Phase 3: 5.4%                  variables not adjusted
              47                                n = 31 059                 selective pre-discharge TSB   Phase 4: 2.5%
                                                mean BW: 3318 ± 457 g mean GA:   measurements (1990–1992)   Phase 5: 1.3%
                                                                           Phase 2:
                                                38.7 ± 1.3 weeks           universal TSB measurement at the   Exchange transfusion
                                                Gender: Males = Not reported   time of metabolic screening with an   (in risk)
                                                                           authority given to nurses (after in-  Phase 1: 1:2137
                                                Ethnicity:                 service workshops and training) to   Phase 2: 1:1322
                                                White = 43.5%              obtain bilirubin estimation at their   Phase 3: 1:1637



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