Page 284 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Gender: Males = 60.1% phototherapy limits as suggested by On comparing correlation coefficient of
the Danish Pediatric Society forehead with that for sternum, knee and
Ethnicity: foot, P < 0.001 for each of the comparison
Non-northern European descent = 9%
Group 2:
Forehead
Group 2: Healthy term and near-term r = 0.87, p > 0.05
infants with GA ≥ 35 weeks in the Sternum
maternity ward r = 0.90, P < 0.05
Knee
n = 227 r = 0.83, P < 0.05
mean BW 3362 g - ange 2170 to Foot
5000 g r = 0.63, P < 0.001
mean GA 38.6 weeks - range 35 to
43 weeks On comparing correlation coefficient of
st
postnatal age at 1 TcB: 74.4 - range forehead with that for sternum, knee and
48 – 360 Gender: Males = 55.5% foot, P < 0.05 for comparison with knee and
foot only
Ethnicity:
Non-northern European descent = 7%
Diagnostic accuracy of TcB (threshold value
Exclusion: > 0.70 times the phototherapy limit) from
babies already receiving phototherapy forehead in detecting TSB > phototherapy
or who received phototherapy 6 hours limit

before TSB measurement,
with skin infection, Group 1 (n = 504 observations):
purpura, Sensitivity: 108/109 (99.1%)
bruising Specificity: 177/395 (44.8%)
PPV: 108/326 (33.1%)
NPV: 177/178 (99.4%)

Group 2 (n = 317 observations):
Sensitivity: 3/3 (100%)
Specificity: 254/314 (80.9%)
PPV: 3/63 (4.8%)
NPV: 254/254 (100%)

Samanta S; Study Type: All babies > 33 weeks in the postnatal TcB using BiliChek (site not Correlation of TcB levels with lab TSB Unselected population
Diagnostic study ward of a regional teaching hospital specified) – single measurement levels (Pearson correlation coefficient, Test & Reference test described
Year: 2004 who were due to have blood taken for taken. n = 300) adequately
Evidence Level: II TSB estimation Test and reference test carried
Country: Reference standard: Laboratory r = 0.77, P < 0.0001 out within one hour
UK n = 300 TSB levels taken concurrently with Blinding – not specified
median BW 3295 g – range 1972 to TcB measurement Bland Altman analysis for difference
44 4720 between TcB and lab TSB
median GA 39 weeks – range 33 to 42 Diagnostic accuracy of TcB
median postnatal age: 72 hours – (various thresholds) estimated by MD = -10.6 micromol/litre (95% CI -80.0 to
range 24 to 264 plotting ROC curve. +60.0)

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