Page 291 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Group 1: before the programme baby managed according to his/her TSB levels ≥ 513 micromol/litre
started from 01 March 2001 to 31 discretion. Group 1 - 1:9742
December 2002, Group 2 - 1:17494
After first 3 months percentile p=0.24
Group 2: after the programme started tracks of the nomogram modified
from 01 January 2003 to 31 December since a large number of babies had Incidence of hospital readmissions for
2004. bilirubin levels in the high or hyperbilirubinaemia
intermediate-high zones
Exclusion: Not defined Group 1 - 0.55%
Group 2 - 0.43%
P < 0.005

Madan A Study type: All babies (n = 4450) of which those Test: Direct Antiglobulin Test Prevalence of DAT positive Data not reliable: authors
Retrospective born to blood type O or Rh negative (DAT) on cord blood. 7.9% (193/2,443) reported not determining the
Year: 2004 observational study mothers (n = 2443) number of DAT negative who
Reference standard: Rate of phototherapy: were treated for jaundice before
Country: USA Evidence level: III Mean GA: Not reported phototherapy/readmission for among DAT positive cases was 18.6% readmission
Mean BW: Not reported phototherapy (36/193).
49 Gender: Not reported Sample: Selective
Ethnicity: Rates for readmission for phototherapy:
Asian = 45.9% among tested babies: 1.1% (26/2,443) Blinding: None
White = 36.8% among untested babies : 0.9% (19/2,097)

Exclusion criteria: None Odds Ratio (OR): 1.18 (95% CI 0.65 – 2.13)

Leistikow EA Study type: All patients in Neonatal Intensive Test: Direct Antiglobulin Test Prevalence of DAT positive: Not reported Small study
Health economics Care Unit; (DAT) on cord blood.
Year: 1995 study babies with clinical jaundice; Percentage of babies tested No definition on readmission
babies with Rh negative mothers Reference standard: Among universal testing (2,253/4,003) for hyperbilirubinaemia given
Country: USA Evidence level: III and/or positive maternal antibody Readmission for jaundice 56.3%
screenings; among selective testing (1,048/4,498) Sample: Non-selective
51 no available maternal blood 23.3%
Blinding: None
Mean GA: Not reported Rate of readmission for hyperbilirubinaemia
Mean BW: Not reported among universally tested babies
Gender: Not reported 0.4 (15/4,003)
Ethnicity: Not reported among selectively tested babies
0.3 (15/4,498)
Exclusion:
Not reported Odds Ratio (OR) 1.12
(95% CI 0.56 – 2.30)

Madlon-Kay DJ Study type All babies in normal nursery cared for Test: Direct Antiglobulin Test Overall Prevalence of DAT positive Small sample
Retrospective cohort by family practice service were (DAT) on cord blood. 9.0% (27/301)
Year: 1992 study: included (n = 301) Test and reference standard not
Reference standard: described in details

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