Page 83 - AIDSBK23C

Page 83

The immunologic categories for clinical classification of HIV infection in children is
based on age-specific CD4 lymphocyte counts and the percent of total lymphocytes as follows:

Immunologic category 1: No evidence of suppression
Immunologic category 2: Evidence of moderate suppression
Immunologic category 3: Severe suppression

Age of child

< 12 months 1-5 years 6-12 years
Immunologic
category
CD4 /µL % CD4 /µL % CD4 /µL %

1: ≥1500 (≥25) ≥1000 (≥ 25) ≥500 (≥ 25)
2: 750-1499 (15-24) 500-999 (15-24) 200-499 (15-24)
3: <750 (<15) <500 (<15) <200 (<15)

Thus, the 1994 CDC classification system for HIV infection can be summarized as follows:

N = No signs or symptoms
A = Mild signs or symptoms
B = Moderate signs or symptoms
C = Severe signs or symptoms

Clinical Categories
Immunologic Categories N A B C

1. No evidence of suppression N1 A1 B1 C1
2. Evidence of moderate suppression N2 A2 B2 C2
3. Severe suppression N3 A3 B3 C3

CRITERIA FOR PERSISTANT GENERALIZED LYMPHADENOPATHY

The original criteria for inclusion of patients into the condition of persistent generalized
lymphadenopathy (PGL) are given below:

* Persistent generalized lymphadenopathy involving two or more extra inguinal sites
lasting 3 months or more
* Absence of an intercurrent disease or illness causing the lymphadenopathy
* Reactive pattern on tissue biopsy