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Drug Effectiveness Review Project
To determine whether long-term DON treatment produces worthwhile improvements in disability,
NHS Executive R&D and Health Authorities in the West Midlands, East Lancashire, Iechyrd
dependency, behavioral, and psychological symptoms or delay in institutionalism
placebo N/A 192 weeks 283 Community residents referred by treating doctor; DSM-IV diagnosis of AD with or without co-existing
Drugs Authors: AD2000 Collaborative Group 38 Morgannwg, and North Nottingham Study design: RCT *Effectiveness trial* Setting: Multi-center (22 memory clinics) donepezil 5 or 10 mg/d 192 weeks 282 VaD; regular caretaker Taking a ChE inhibitor or a contraindication against DON All medications except other AChE inhibitors
Alzheimer Year: 2004 Country: UK Sample size: 565
Final Report Update 1 Efficacy/Effectiveness STUDY: FUNDING: RESEARCH OBJECTIVE: DESIGN: INTERVENTION: Dose: Duration: Sample size: INCLUSION: EXCLUSION: OTHER MEDICATIONS/ INTERVENTIONS ALLOWED: Alzheimer's Drugs
