Page 57 - Drug Class Review

Final Report Update 1 Drug Effectiveness Review Project

Figure 1: Results of literature search

Titles and abstracts Citations excluded:
identified through
searches: n = 925
n = 1167

Abstracts only:
n = 36

Full text articles excluded:
Unable to retrieve:
n = 6 n = 71

• 2 Not English language
Full-text articles • 6 Wrong outcomes
retrieved: • 4 Drug not included
• 7 Population not included
n = 200 • 19 Wrong publication type
• 33 Wrong study design

Background:

n = 59

Articles included in drug class review:
Poor methodological quality:
n = 70 n = 15

for efficacy:
• 4 on head-to-head trials • 6 on pooled data
• 42 on placebo controlled trials analysis
• 13 on systematic reviews or meta- • 8 on RCTs
analyses for adverse events:
• 11 on studies, other design (e.g. pooled • 1 observational cohort
data) study

Alzheimer's Drugs Page 57 of 205