Page 60 - Noninvasive Diagnostic Techniques for the Detection of Skin Cancers
P. 60

Appendix D. Evidence Maps and Outcome Measures



                                                        a
 Table D-1. Evidence map of published abstracts for noninvasive diagnostic devices by clinical use status (N=583 )
    Reviews (N=232)         Primary Studies (N=351)
                                                                        Single
 Narrative   Technical   Systematic   Comparative   Non-comparative   Diagnostic
 Noninvasive technologies   RCT                                         case
 reviews   reports   reviews   cohorts   cohorts         tests         reports

 Modalities in general clinical use
      b
 Photography   4   4   --   7    11    13                  5               -
 Dermoscopy   78   71   5   3   39     96                 52              49
 Subtotal   81   74   5   10   50     109                 57              49
 Modalities in limited clinical use
 Confocal microscopy   17   12   --   --   6   26          7              4
 Ultrasound/Laser Doppler   6   12   --   --   2   7       7              --
 Photodynamic diagnosis   9   7   --   1   4   --          --             1
 Subtotal   32   31   0   1   12       33                 14              5
 Investigational
 Multiphoton laser scanning   3   --   --   --   --   --   2              --
 microscopy
 Multispectral imaging and
 c
 fully automated computer-  1    --   --   --   --   --    1              --
 based analysis
 Electrical bio-impedance   --   --   --   --   1   2      2              --
 Optical coherence   1   2   --   --   1   1               --             --
 tomography
 Tape stripping   --   --   --   --   --   --              1              --
 Thermography   1   --   --   --   --   --                 --             --
 Subtotal   6   2   0   0   2           3                  6              0

 Total   119   108   5   11   64      144                 77              55
 a  Subset of 629 abstracts designated as either a review article or primary study focusing on a single diagnostic modality, some review articles have been counted in more than one
 category, therefore , the individual numbers may not sum up to the subtotal.
 b  6 unique RCTs produced 7 individual abstracts.
 c  Review also covered other topics (e.g., dermoscopy).













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