Page 78 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Imaging. One cohort performed annual bone scan for the first 2 years and biennially
thereafter. 114,125,129,130 Another cohort reported that magnetic resonance imaging of the prostate
was selectively performed every 1 to 3 years during followup. 109

Behavioral indicators. No study based used a formal assessment of any behavioral indicator to
initiate active treatment as part of their followup protocol, but one cohort explicitly reported that
108
some patients requested treatment due to anxiety related to increasing PSA.
a
Figure 5. Followup frequencies of 16 unique AS cohorts
Year 1 2 3 4
AS cohort Month 3 6 9 12 15 18 21 24 27 30 33 36 39 42 45 48
Baylor College PSA-test √ √ √ √ √ √ √ √ √ √
of Medicine DRE √ √ √ √ √ √ √ √ √ √
and MSKCC 106 Rebiopsy √
PSA-test √ √ √ √ √ √ √ √
McGill √ √ √ √ √ √ √ √
University 107 DRE
Rebiopsy √ √ √ √
PSA-test √ √ √ √ √ √ √ √
UCHC 108 DRE √ √ √ √
Rebiopsy √
Four academic PSA-test √ √ √ √
medical DRE √ √ √ √
canters 109 Rebiopsy within 18 mo; then every 1 to 3 yr
√ √ √ √ √ √ √ √
PSA-test * * * * * * * * √ √ √ √
University of
Miami 110 √ √ √ √ √ √ √ √
DRE * * * * * * * * √ √ √ √
Rebiopsy within 9-12 mo √ √ √
PSA-test √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √
UCSF 111 DRE √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √
Rebiopsy √ √
PSA-test √ √ √ √ √ √ √ √
Royal Marsden
Hospital 112 DRE √ √ √ √ √ √ √ √
Rebiopsy not routine
PSA-test √ √ √ √ √ √ √ √
Johns √ √ √ √ √ √ √ √
Hopkins 113 DRE
Rebiopsy √ √ √ √
PSA-test √ √ √ √ √ √ √ √ √ √ √ √
Toronto 114 DRE
Rebiopsy √**
Bone scan √ √ √
PSA-test √ √ √ √ √ √ √ √
MSKCC 115 DRE √ √ √ √ √ √ √ √
Rebiopsy within 12-18 mo; then every 2 to 3 yr
PSA-test √ √ √ √ √ √ √ √ √ √
ProtecT 116 DRE
Rebiopsy not routine
Dana-Farber PSA-test √ √ √ √ √ √ √ √
Cancer DRE √ √ √ √ √ √ √ √
Institute 117 Rebiopsy √ √ √

39