Page 75 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Table 3. Eligibility criteria for enrollment in protocols with curative intent in chronological order of starting enrollment year (continued)
Center, Country Term used in Age Gleason score # biopsy PSA Imaging Stage Behavioral indication (other
[Pubmed ID] original article (yr) cores /% (ng/mL) than patients’ choice or
Enrollment years cores preference)
PASS, US 121 AS – – If diagnosis ≤1 – – Clinical stage –
[19758683] year of entry, at T1-2, NX/0,
least 1 biopsy MX/0
e
2008 – ongoing with ≥10 cores.
If diagnosis >1
year of entry,
minimum of 2
biopsies; 1 ≤2
years before
entry.
DT = doubling time; PSA = prostate-specific antigen; TNM = tumor-node-metastasis system; TURP = transurethral resection of the prostate; yr = yr(s); wk = wk(s); mo = mo(s);
SRCC = Sunnybrook Regional Cancer Center; BCCA = the British Columbia Cancer Agency; DRE = digital rectal examination; WW = watchful waiting; AS = active
surveillance; EM = expectant management; PAP = prostate acid phosphatase; PSA = prostate specific antigen; TRUS = Transrectal ultrasound; CT = computerized tomography;
PSA = prostate-specific antigen; TNM = tumor-node-metastasis system; SRCC = Sunnybrook Regional Cancer Center; BCCA = the British Columbia Cancer Agency; ED =
erectile dysfunction; PRIAS = Prostate cancer Research International Active Surveillance; ProtecT = Prostate testing for cancer and Treatment; UCSF=University of California at
San Francisco; European Randomized Study of Screening for Prostate Cancer = ERSPC; VA = Veterans Affairs; MSKCC = Memorial Sloan-Kettering Cancer Center
√ = item was used as part of monitoring strategy but explicit criteria were not defined
– = item was not used or not reported as part of monitoring strategy

a Cleveland Clinic Foundation, Memorial Sloan-Kettering Cancer Center, University of British Columbia and University of Miami
b Multiple terms used across multiple publications and within single publication
c Since January 2000, Toronto-SRCC study was restricted to low-risk patients only.
d PRIAS protocol can be found: http://www.erspc-media.org/media/publications/PRIAS%20Project_background.pdf. Accessed September 28, 2011.
e Prostate Active Surveillance Study (PASS) protocol can also be found at Clinicaltrial.gov (NCT00756665): http://clinicaltrials.gov/ct2/show/NCT00756665. Accessed September
28, 2011.

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