Page 540 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C4.4. Comparison between watchful waiting and other active treatments

Author Study name Comparison Outcome Followup Sample Results Factors included in the model
Year /Database definition/ (yr) size per
Pubmed id measurement group
instrument
Prostate
cancer-
specific
mortality
Wong 208 SEER- Active Death from 12 yr Active HR=0.67 (0.58, 0.77) PS: age at diagnosis, SEER site,
2006 Medicare treatment prostate treatment: year of diagnosis, tumor size, tumor
17164454 (RP or BT or cancer based 32,022 grade, marital status, residence in
RT on the cause an urban setting, race, income,
Retrospective considered of death Observation: educational achievement, and 44
cohort in reported in 12,608 categorical variables encoding
aggregate) SEER. Data comorbidities. The authors reported
vs. on cause- a statistically significant interaction
observation specific between tumor size and grade.
mortality were
available For the association of treatment
through the and survival in the entire cohort,
end of 2000. estimates were adjusted for the PS
and comorbidities, tumor grade,
and tumor size as categorical
variables.
All-cause
mortality
Wong 208 SEER- Active Overall 12 yr Active HR=0.69 (0.66, 0.72); PS: age at diagnosis, SEER site,
2006 Medicare treatment survival = treatment: stratified by PS quintile, year of diagnosis, tumor size, tumor
17164454 (RP or BT or interval from 32,022 HR 0.67 (0.65-0.70) grade, marital status, residence in
RT the date of an urban setting, race, income,
Retrospective considered diagnosis to Observation: educational achievement, and 44
cohort in the Medicare 12,608 categorical variables encoding
aggregate) dare of death. comorbidities. The authors reported
vs. Patients were a statistically significant interaction
observation censored at between tumor size and grade.
Dec. 20, 2002.
For the association of treatment
and survival in the entire cohort,
estimates were adjusted for the PS
and comorbidities, tumor grade,
and tumor size as categorical
variables.

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