Page 538 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C4.3. Comparison between watchful waiting and radiation therapy (continued)
Author, Year Study name Comparison Outcome Followup Sample size Results Factors included in the
[Pubmed ID] /Database definition/ (yr) per group model
measurement
Study design instrument
Observation Prostate 2 yr post- Observation: Estimates are means (SE) Treatment group interaction
vs. RT cancer- treatment 87 based on linear mixed model for with time, age, time of
specific QoL regression RT: 75 Observation vs. RT: treatment.
items. All estimates Urinary function, 87.4 (5.1);
scales were 84.9 (4.7) P values for comparisons
scored 0 to Bowel function, 89.1 (3.9); 83.1 between treatment groups
100; optimal (3.5) NR.
health or Sexual function, 29.1 (4.9); 25.4
functioning = (4.5)
100. Urinary bother, 83.6 (6.7); 65.1
(6.2)
Bowel bother, 90.0 (5.6); 74.8
(5.3)
Sexual bother, 24.9 (8.8); 32.4
(8.1)
CaP interference: family
function, 86.9 (4.6); 84.7 (4.2)
CaP interference, 87.0 (4.1);
83.1 (3.7)
ADT = androgen deprivation therapy; BT = brachytherapy; HR = hazard ratio; MANOVA = multivariate analysis of variance; NR = not reported; RP = radical prostatectomy;
RT = radiation therapy.

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