Page 519 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C4.3. Comparison between watchful waiting and radiation therapy
Author, Year Study name Comparison Outcome Followup Sample size Results Factors included in the
[Pubmed ID] /Database definition/ (yr) per group model
measurement
Study design instrument
Prostate
cancer-
specific
mortality
Stattin 223 NPCRSFS RT vs. Death from Median Surveillance: HR=0.70 (0.45, 1.09) Age at diagnosis,
2010 surveillance prostate followup= 2021 comorbidity, socioeconomic
20562373 cancer as 8.2 yr RT: 1429 group, risk group.
“underlying (IQR=7.1-
Retrospective cause of 9.7 yr)
cohort death,” data
obtained from
the Cause of
Death
Register or
review of
death
certificates
All-cause
mortality
Wong 208 SEER- Radiation Tx Overall 12 yr RT: 18,249 HR=0.81 (0.78, 0.85) PS: age at diagnosis, SEER
2006 Medicare vs. survival = Observation: site, year of diagnosis,
17164454 observation interval from 12,608 tumor size, tumor grade,
the date of marital status, residence in
Retrospective diagnosis to an urban setting, race,
cohort the Medicare income, educational
dare of death. achievement, and 44
Patients were categorical variables
censored at encoding comorbidities. The
Dec. 20, 2002. authors reported a
statistically significant
interaction between tumor
size and grade.

For treatment subgroups
(RP and radiation Tx)
separate PS were built and
used as covariates in the
Cox regression models.

C-177