Page 498 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C4.2. Comparison between watchful waiting and radical prostatectomy (continued)
Author, Year Study name Comparison Outcome Followup Sample size Results Factors included in the
[Pubmed ID] /Database definition/ (yr) per group model
measurement
Study design instrument
a
Berge 231 SEER- WW vs. RP Cystoscopy; 5 yr WW: 3612 HR=1.00 (0.88, 1.13) for Age, grade, comorbidity
2007 Medicare bladder RP: 3940 cystoscopy; P=0.071 for the index
17178188 irrigation/ null hypothesis that the
cystostomy; coefficients of all treatments
Retrospective TURP/bladder- entered in the model are 0
cohort neck incision;
urethra dilation HR=1.71 (1.33-2.20) for
[procedures bladder irrigation/
considered cystostomy; P<0.001 for the
indicative of null hypothesis that the
treatment- coefficients of all treatments
related entered in the model are 0
morbidity]
HR=2.63 (2.08, 3.33) for
TURP/bladder-neck incision;
P =0.008 for the null
hypothesis that the
coefficients of all treatments
entered in the model are 0

HR=0.71 (0.61, 0.84) for
urethra dilation; P =0.309 for
the null hypothesis that the
coefficients of all treatments
entered in the model are 0
Quality of life
Johansson 214 Ancillary WW vs. RP 77 questions Mean RP: 189 (166 Last 6 mo; 2-3 yr post NR (RCT)
2009 investigation on quality of life followup: responders) randomization
18783877 from SPCG-4 (developed 4.1 yr WW: 187 Anxiety (moderate or high):
trial based on (range: 1- (160 RR=0.5 (0.2, 1.0)
RCT interviews, 8) responders) Depressed mood (moderate
tested for face [Some of the or high): RR=0.6 (0.3, 1.0)
validity on 30 responders Sense of well-being (low or

a In multivariable analysis this study used RP as the baseline treatment, thus adjusted estimates were reported for the comparison of RP with each other treatment
(i.e., WW, RT, ADT). For the comparison of WW with other active treatments (i.e., WW vs. RT and ADT vs. RT) only unadjusted estimates were reported in the
paper and were not extracted here. For more details please see the Methods section.

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