Page 378 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C2.1. Eligibility criteria, follow-up protocols, triggers for intervention and definition of progression in cohorts of active
surveillance/ watchful waiting/other observational management strategies (continued)

Center, Country Eligibility criteria Followup or monitoring protocol Triggers for intervention/ Definition of
[PMID] active therapy progression
Enrollment year
[12226148] localized levels. as a treatment for local palpable; symptoms
prostate cancer, A bone scan and chest radiograph were obtained every 1 yr progression. of obstruction of the
1989-1999 < 75 yr, with life after start of the study. After 1996, chest x-ray films were flow of urine that
expectancy of obtained annually for the first 2 yr. necessitated
>10 yr, T stage Rebiopsy was not routinely undertaken. 152 intervention, or both.
of T0d, T1 or
T2, eligible for
radical
prostatectomy,
well
differentiated to
moderately well
differentiated
tumor, negative
bone scan, PSA
level < 50
ng/mL.
After 1994, men
with T1c tumors
— according to
the revised
1987
International
Union against
Cancer
classification —
were also
eligible.
Men with a poorly
differentiated
tumor were not
eligible.
Patients whose
condition was
diagnosed with
an extended
biopsy protocol
were accepted
if <25% of the

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