Page 366 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C2.1. Eligibility criteria, follow-up protocols, triggers for intervention and definition of progression in cohorts of active
surveillance/ watchful waiting/other observational management strategies (continued)

Center, Country Eligibility criteria Followup or monitoring protocol Triggers for intervention/ Definition of
[PMID] active therapy progression
Enrollment year
Orebro Medical Patients were Every 6 to 12 mo, patients were followed with clinical exam, lab Patients were treated NR
Center, Sweden 139 given no initial tests including PAP and bone scans. hormonally if disease
[7933233] treatment if the PSA was only performed during the last few yr. progressed for they had
tumor was symptoms of progression.
1977-1984 localized to the
prostate gland
without
penetration of
the capsule on
DRE (stages T0
to T2) and there
was no
evidence of
distant
metastases.
However,
several
restrictions
were applied to
those with a
palpable tumor
(stages T1 to
T2).
From March 1978
to Feb. 1979,
patients >75 yr
were not given
any initial
treatment
(deferred
treatment).

C-101