Page 365 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C2.1. Eligibility criteria, follow-up protocols, triggers for intervention and definition of progression in cohorts of active
surveillance/ watchful waiting/other observational management strategies (continued)

Center, Country Eligibility criteria Followup or monitoring protocol Triggers for intervention/ Definition of
[PMID] active therapy progression
Enrollment year
Northern Patients with Followup was performed every 3 to 6 mo for the first 2 yr and Treatment was offered to the Clinical progression:
Stockholm, clinically every 6 to 12 months thereafter with DRE and PAP. Re- patients if clinical positive bone scan
Sweden 140 localized biopsies were done every year during the first 4 yr, and a progression with symptoms or plain x-ray for the
[17467883] prostate cancer, bone scan was repeated every 12 to 18 mo. occurred. diagnosis of skeletal
diagnosed by metastases.
1978-1982 biopsies and
cytological
assessment,
initially
managed with
WW.
Patients with
palpable tumors
(71% T1-2 and
29% with T3)
were included
in a prospective
surveillance
protocol with
close follow-up.
Bone scan and
PAP were
normal in all
patients.

C-100