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Guidelines for the treatment of malaria – 2
Guidelines for the treatment of malaria – 2 edition edition

importance CRITICAL CRITICAL IMPORTANT CRITICAL

Quality HIGH VERY LOW VERY LOW
LOW

84 fewer per 1000 (from 56 to 109 fewer) 6 more per 1000 (from 2 fewer (–1.34 to 1.54) 146 fewer per 1000 (from 35 fewer

Absolute to 33 more) MD 0.10 to 203 fewer)

effect Relative risk (95% CI) RR 0.62 (0.51– 0.75) RR 2.21 (0.64–7.63) – RR 0.46 (0.25–0.87)
Is artesunate superior to quinine for treating severe malaria in endemic areas?

summary of findings no. of patients QN AS 214/963 133/975 (22.2%) (13.6%) 3/597 8/656 (0.5%) (1.2%) 54 59 24/89 12/96 (27%) (12.5%)

Imprecision No serious imprecision Very serious 5 Very serious 5 No serious imprecision

Indirectness No serious indirectness 2 Serious 4 No serious indirectness Serious 9

Inconsistency No serious inconsistency No serious inconsistency Not applicable 7 No serious inconsistency

Limitations No serious 1 limitations No serious limitations 3 Very serious 6 Serious 8

GRADE Table A8.1.1 Quality assessment Design EFFICACy: death Randomized trial EFFICACy: neurological sequelae at discharge Randomized trial EFFICACy: time to hospital discharge (days) Randomized trial HARMS: hypoglycaemia (routine monitoring) Randomized trial

156 No. of studies 6 2 1 2