Page 341 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

What should be included in a formal assessment of a baby with neonatal hyperbilirubinaemia?

Evidence Table – Assessment Tests
TSB < 255micromol/litre

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Author: Werblinska B Study type: Diagnosis: Jaundice Mean bilirubin levels Small study,
Case–control study Criteria: TSB ≥ 171 micromol/litre TSB: 253 micromol/litre
Year: 1981 Setting: Hospital Incomplete data from three subject so
Evidence level: 2 ABO incompatibility: 8/40 (20%) not included in analysis
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Country: Nigeria Sample Size: 40
GA: Not reported Rh incompatibility: 3/40 (7.5%) All 38controls (14 M & 24 F) were
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Ref ID: Mean BW: Not reported. delivered by Caesarean Section due to
Gender M/F: 19/21 G6PD deficiency: 13/40 (32.5%) maternal complication
Ethnicity: Not reported P value < 0.001
Exclusion: None
Infection: 34/40 (85%)
P value < 0.001

Idiopathic: 3/40 (7.5)
Author: Azubuike J Study type: Diagnosis: Jaundice Mean bilirubin levels
Case series Criteria: TSB ≥ 170 micromol/litre TSB: Not reported
Year: 1979 Setting: Hospital
Evidence level: 3 Sample Size: 424 ABO incompatibility: 178/424 (41.2%)
Country: Nigeria GA: Not reported
Mean BW: Not reported Rh incompatibility:2/424 (0.5%)
Ref ID: Gender M/F: Not reported
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Ethnicity: Not reported G6PD deficiency:
Breastfeeding: Not reported 229/424 (54%)
Onset of Jaundice: Days 0 – 10
Infection: 60/424 (14.1%)
Exclusion: None
Idiopathic: 39/424 (9.2%)
Author: Guaran R Study type: Diagnosis: Jaundice Mean bilirubin levels 4815 cases had no investigations
Retrospective chart Criteria: TSB ≥ 154 micromol/litre TSB: Not reported Preterm birth is reported to be the
Year: 1992 review Setting: Hospital most common cause 2226/61290
ABO incompatibility: 601/6129 (9.8%) (36.3%)
Country: Australia Evidence level: 3 Sample Size: 10944
GA: Not reported. Rh incompatibility:193/6129 (3.1%)
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Ref ID: Mean BW: Not reported
Gender M/F: Not reported G6PD deficiency:
Ethnicity: Not reported 51/6129 (0.8%)
Breastfeeding: Not reported
Onset of Jaundice: Not reported Infection: 198/6129 (3.2%)

Exclusion: None (4,815 Not investigated) Exchange Transfusion (n = 248)
ABO incompatibility: 58/248 (23.4%)

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