Page 336 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Mean BW: Not reported VITROS: r² = 0.66 Blinding – No
81 Median GA: 39.9 weeks (32.7 to 41.4) Reference standard:
Gender: Not reported 1.Laboratory TSB diazo method
Ethnicity: measured on blood collected within Diagnostic accuracy of TcB (threshold value
White = 82.5% 30 minutes as TcB. >75 centile on Bhutani nomogram
Black = 1.7%
Hispanic = 5.1% 2. Laboratory TSB VITROS Diazo:
Asian = 10.7% method measured on blood Sensitivity: 56/57 (98.2%)
collected within 30 minutes as TcB. Specificity: 48/120 (40%)
Exclusion: PPV: 56/127 (43.7%)
None NPV: 48/49 (98%)

Vitros:
Sensitivity: 63/67 (94%)
Specificity: 35/64 (54.7%)
PPV: 63/92 (68.5%)
NPV: 35/39 (89.7%)

Slusher TM; Study Type: Clinically jaundiced term and preterm TcB using BiliChek from the Correlation of TcB levels with lab TSB Unselected population
Diagnostic study babies with age < 14 days admitted in forehead and before starting levels (Pearson correlation coefficient) Test & Reference test described
Year: 2004 two hospitals phototherapy adequately
Evidence Level: Both hospital together Test and reference test carried
Country: II n = 127 Skin pigmentation determined r = 0.92 out within one hour
Nigeria mean BW: 2.72 ± 0.62 kg through visual observation Babies with TSB ≥ 205 micromol/litre Blinding – yes but only
r = 0.84 investigator
80 mean GA: Not reported Reference standard: Laboratory Babies with TSB < 205 micromol/litre Data not extractable for
Gender: Males = 60%, TSB levels obtained r = 0.67 calculating values of TP, FP,

simultaneously with TcB TN & FN for detecting hyperbil
Pigmentation – measurement Based on pigmentation
dark pigmentation 10%
medium pigmentation = 36% Light: r = 0.91
light pigmentation = 54% Medium: r = 0.94
Dark: r = 0.87

Hospital A: 500-bed tertiary teaching Bland Altman analysis for difference
hospital (n = 98) between mean TcB and mean lab TSB

Hospital B: 168-bed hospital located in a values
rural village (n = 29) Both hospitals together
MD = 8.5 micromol/litre (95% CI -3.4 to
21.4 micromol/litre
Exclusion: not defined
SD = 129.2 micromol/litre

Babies with TSB ≥ 205 micromol/litre
MD = --21.4 micromol/litre (95% CI -40.8
to 0.0 micromol/litre)
SD = 146.2 micromol/litre

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