Page 278 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test

Chen JY; Study Type: Healthy term babies born to blood Small sample and data derived
Diagnostic accuracy group O, Rh positive mothers and Test 1: Prevalence of DAT positive from results of two groups of
Year: 1994 study weighing = 2.5 kg with no evidence Direct Coombs’ test from cord 14/53 (26.4%) babies with blood group A & B
blood.

of perinatal asphyxia, polycythemia, Prevalence of hyperbilirubinaemia only
Country: Taiwan Evidence Level: III huge cephalhematoma or infection. Test 2: UCB levels measured 29/53 (54.7%) Test & Reference test not
(n = 88) described in detail
40 threshold value > 68 micromol/litre Reference test is a standard one
Mean GA: Not reported Diagnostic accuracy of Coombs’ test for Blinding: none
predicting hyperbilirubinaemia (n = 53)
Mean BW: Not reported Reference standard:
Gender: Not reported Hyperbilirubinaemia defined as Sensitivity: 13/29 (44.8%)
Ethnicity: Not reported
TSB levels = 256 micromol/litre) Specificity: 23/24 (95.8%)
Exclusion: not defined within first 4 days of life and/or PPV: 13/14 (92.8%)
NPV: 23/39 (59.0%)
early jaundice with TSB
levels = 171 micromol/litre within
24 hours of birth Diagnostic accuracy of UCB (>
68 micromol/litre for predicting
hyperbilirubinaemia (n = 53)

Sensitivity: 12/29 (41.4%)
Specificity: 24/24 (100%)
PPV: 12/12 (100%)
NPV: 24/41 (58.5%)

Sarici SU Study type: All full-term babies (GA > 38 weeks) Aim of study was to see if 6hr
Prospective with blood groups A or B born to Test: Direct Antiglobulin Test Prevalence of DAT positive TSB levels predicted
Year: 2002 diagnostic study mothers with blood group O without (DAT) on cord blood 4.4% (6/136) hyperbilirubinaemia

simultaneous Rhesus blood factor Reference standard: Total serum Prevalence of Hyperbilirubinaemia
Country: Turkey Evidence level: III incompatibility. (n = 150) No data on 14 babies for
bilirubin level (TSB) at 6, 30, 54, 29/136 (21.3%) clinical or consent reasons
39 78 and 102 hours
Mean GA: 39.4 ± 1.2 weeks Hyperbilirubinaemia was defined Accuracy of DAT in predicting Selected sample and test not
hyperbilirubinaemia (n = 136)
Mean BW: 3212 ± 415 g as: described.
Gender: Males = 50.7% TSB ≥ 85 micromol/litre and Sensitivity: 6/23 (20.1%)
Ethnicity: Not reported Reference is a standard test and
increase of 8.5 micromol/litre per Specificity: 107/107 (100%) was adequately described
hour in first 24 hours PPV: 6/6 (100%)
Day 2 TSB > 205 micromol/litre NPV: 107/130 (82.3%)
Day 3 TSB > 256 micromol/litre Blinding: None
Day 4/5 TSB > 290 micromol/litre

Meberg A Study Type: All babies born in a general hospital. Test: Direct Antiglobulin Test Prevalence of DAT positive Universal sample
Diagnostic Accuracy (n = 2463)
Year: 1998 study (DAT) on cord blood 4.1% (100/2,463) Test: not adequately described
Mean GA: Not reported (94.8% were Reference: TSB levels requiring Prevalence of Hyperbilirubinaemia
Country: Norway Evidence level: III term babies ≥ 27 weeks) Reference test is a standard one

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