Page 277 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
predicting hyperbilirubinaemia in babies of
non-smoking mothers (n = 499)
Sensitivity: 17/61 (27.9%)
Specificity: 429/438 (97.9%)
PPV: 17/26 (65.4%)
NPV: 429/473 (90.7%)

Risemberg HM; Study Type: All consecutive newborns of hetero- Test 1: Coombs’ test done on cord Prevalence of severe hyperbilirubinaemia Small sample
Prospective specific pregnancies (blood group O blood of all newborn babies. 13/91 (14.3%) Test and Reference standard
Year: 1977 diagnostic study mothers with babies having blood not described in details
group A or B) born in two hospitals Test 2: UCB levels measured Prevalence of DAT positive Reference test a standard one
Country: USA Evidence Level: III (n = 91) (threshold value 31/91 (34.1%) Blinding – Not reported
> 68 micromol/litre)
42 Mean GA: Not reported Accuracy of positive DAT test in predicting
Mean BW: Not reported Reference standard: severe hyperbilirubinaemia (n = 91)
Gender: Not reported Severe hyperbilirubinaemia defined Sensitivity: 12/13 (92.3%)
Ethnicity: Not reported as TSB > 274 micromol/litre at 12– Specificity: 59/78 (75.6%)
36 hours of age PPV: 12/31 (38.7%)
Exclusion: Rh incompatible babies NPV: 58/60 (98.3%)
Accuracy of UCB levels (threshold >
68 micromol/litre) in predicting severe
hyperbilirubinaemia (n = 91)
Sensitivity: 12/13 (92.3%)
Specificity: 78/78 (100%)
PPV: 12/12 (100%)
NPV: 78/79 (98.7%)

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