Page 247 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Exclusion: not defined hyperbilirubinaemia phase 2 (46/1324)

1. For UCB
(threshold = 37 micromol/litre)
Sensitivity: 4/18 (22.2%)
Specificity: 537/567 (94.7%)

2. At 24 hours
For TcB in phase 1 (threshold > 11
Reflectance Units)
Sensitivity: 15/18 (83.3%)
Specificity: 368/556 (66.2%)
PPV: 15/203 (7.4%)
NPV: 368/371 (99.2%)

For TSB in phase 1
(threshold = 102 micromol/litre)
Sensitivity: 7/7 (100%)
Specificity: 74/162 (45.7%)
PPV: 7/95 (7.4%)
NPV:74/74 (100%)

For TSB in phase 2
(threshold = 102 micromol/litre)
Sensitivity: 25/25 (100%)
Specificity: 239/398 (60%)
PPV: 25/95 (26.3%)
NPV: 239/239 (100%)

2. At 48 hours
For TcB in phase 1 (threshold > 13
reflectance units)
Sensitivity: 17/18 (94.4%)
Specificity: 288/556 (51.7%)
PPV: 17/285 (5.9%)
NPV: 288/289 (99.6%)

For TcB in phase 2 (threshold > 13
reflectance units)
Sensitivity: 45/46 (97.8%)
Specificity: 262/819 (32.0%)
PPV: 45/602 (7.5%)
NPV: 262/263 (99.6%)

For TSB in phase 1
(threshold = 154 micromol/litre)
Sensitivity: 11/11 (100%)
Specificity: 102/158 (64.6%)

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