Page 249 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
PPV: 11/67 (16.4%)
NPV: 101/102 (100%)

For TSB in phase 2
(threshold = 154 micromol/litre)
Sensitivity: 45/46 (97.8%)
Specificity: 348/774 (45%)
PPV: 45/471 (9.5%)
NPV: 348/349 (99.7%)

Agarwal R; Study Type: All infants with GA > 35 weeks with Test: Diagnostic accuracy of TSB (threshold Unselected population
Diagnostic study no significant illness requiring NICU TSB at 24 ± 6 hours after birth – value > 102 micromol/litre) for predicting Test & Reference test described
Year: 2002 admission for > 12 hours, absence of TSB = 290 micromol/litre (n = 213) in detail
Evidence Level: 1b any major congenital malformations three samples taken and mean of Reference test a standard one
Country: and residing near hospital whose two closest values taken for Prevalence: 22/213 (10.3%) Blinding – yes
analysis
India parents agreed to come for follow-up. Sensitivity: 21/22 (95.4%)
Specificity: 135/191 (70.7%)
27 n = 220 Threshold value: PPV: 21/77 (27,3%)
mean GA 38 ± 1.4 weeks > 102 micromol/litre NPV: 135/136 (99.3%)

mean BW 2827 ± 459 g Reference standard: Laboratory
TSB measured on Day 5 when
Gender: Males = 53.3% clinical jaundice
Ethnicity: Not reported
> 171 micromol/litre
Exclusion:
babies requiring NICU admission, TSB ≥ 290 micromol/litre taken as
indicative of hyperbilirubinaemia
Rh hemolysis.

Alpay F; Study Type: All healthy full term newborn babies Test: Diagnostic accuracy of TSB for predicting Unselected population
Diagnostic study with GA = 38 weeks. TSB within first 24 hours (mean TSB = 290 micromol/litre (n = 498) Test & Reference test described
Year: 2000 17.1 hours) in detail
Evidence Level: II n = 498 Threshold value = 102 micromol/litre Reference test a standard one
Country: mean GA Not reported ROC curve used for threshold Prevalence: 60/498 (12.0%) Blinding – Not reported
Turkey mean BW Not reported value with highest sensitivity for Sensitivity: 54/60 (90%)
Gender: Not reported predicting hyperbilirubinaemia Specificity: 286/438 (65.3%)
28 Ethnicity: Not reported (threshold PPV: 54/206 (26.2%)
value: = 102 micromol/litre) NPV: 286/292 (97.9%)
Exclusion:
babies with blood groups A, AB, B Results also given for threshold Threshold value = 120 micromol/litre
and O/Rhesus blood factor values = 120 micromol/litre Sensitivity: 36/60 (60%)
incompatibility and a positive direct and = 137 micromol/litre
antiglobulin test result Specificity: 363/438 (82.9%)
G6PD deficiency Reference standard: Laboratory PPV: 36/111 (32.4%)
NPV: 363/387 (97.8%)
TSB measured at 24 hours interval
for next 4 days Threshold value = 137 micromol/litre

Sensitivity: 21/60 (35%)

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