Page 243 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
PPV: 5/46 (10.9%)
NPV: 32/32 (100%)

Diagnostic accuracy of UCB (threshold >
30 micromol/litre) in predicting need for
phototherapy
Group 1:
Prevalence: 40/1100 (3.6%)
Sensitivity: 36/40 (90%)
Specificity: 439/1060 (41.4%)
PPV: 36/657 (5.5%)
NPV: 439/443 (99.1%)

Group 2:
Prevalence: 17/163 (10.4%)
Sensitivity: 16/17 (94.1%)
Specificity: 69/146 (47.3%)
PPV: 16/93 (17.2%)
NPV: 69/70 (98.6%)

Group 3:
Prevalence: 37/78 (47.4%)
Sensitivity: 26/37 (70.3%)
Specificity: 21/41 (51.2%)
PPV: 26/46 (56.5%)
NPV: 21/32 (65.6%)

Taksande A; Study Type: Healthy full term babies born in the Test: Diagnostic accuracy of UCB (threshold Unselected population
Diagnostic study hospital with GA > 37 weeks and Umbilical cord blood bilirubin value > 2 mg% or 34 micromol/litre) for Test & Reference test not
Year: 2005 absence of significant illness requiring (UCB) measured at birth predicting TSB > 17 mg% or described in detail
Evidence Level: II NICU admission and any congenital Threshold value 290 micromol/litre Reference test is a standard one
Country: malformation. > 34 micromol/litre Blinding – yes
India Prevalence: 19/200 (9.5%)
n = 200 Reference standard: Laboratory Sensitivity: 17/19 (89.5%)
31 TSB measured after 72 hours Specificity: 154/181 (85.1%)
mean GA 38.9 ± 2.07 weeks PPV: 17/44 (38.6%)
mean BW 2555 ± 442 g TSB > 290 micromol/litre taken as NPV: 154/156 (98.7%)
Gender: Males = 41% hyperbilirubinaemia
Ethnicity: Not reported

Exclusion:
babies with ABO or Rh
incompatibility,
G6PD deficiency,
those who later developed significant
illness requiring NICU admission.

Knudsen A; Study Type: Healthy term babies admitted to the Test: Diagnostic accuracy of UCB (threshold Unselected population

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