Page 221 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type and Patient characteristics Methodology and interventions Results Reviewers Comments
Evidence level
Risk index score 16–19
+LR: 2.0
Risk index score 20–23
+LR: 2.6
Risk index score > 24
+LR: 3.2

PRE-DISCHARGE TSB

c-statistic 0.83 (0.80–0.86)

th
TSB centile 0–40
+LR: 0.05
th
TSB centile 41–75
+LR: 0.2
th
TSB centile 76–95
+LR: 2.2
th
TSB centile > 95
+LR: 9.4

Seidman DS et al.; Study Type: Healthy full term infants with 1) Association of various factors 1) Factors associated with jaundice after Unselected population
Prospective cohort GA = 37 weeks born at two with jaundice derived from comparing Group 1 vs Group 2 (n = 1,177) No differences at baseline between the two
Year: 1999 study hospitals multiple regression analysis groups
Day 1 TSB (per 17 micromol/litre)
Country: Evidence Level: II n = 1177 2) Comparison of diagnostic OR: 3.1 (95% CI 2.4 to 4.1) Test & Reference test described in detail
Israel mean BW 3247 ± 453 g accuracy of various tests for Reference test a standard one
Change in TSB from day 1 to day 2 (per Blinding – Not reported
13 mean GA 39.8 ± 1.3 weeks predicting hyperbilirubinaemia 17 micromol/litre) Confounding factors adjusted for during
Gender: Males = 47.3% OR: 2.4 (95% CI 1.9 to 3.0) modelling
Ethnicity: Not reported Test:
TSB measured within first 8 to Maternal age (per year) Data not available to calculate PPV or
Exclusion: 24 hours of life and repeated OR: 1.1 (95% CI 1.0 to 1.2) NPV. Raw figures not available
ABO or Rh incompatibility and a daily for the next 4 days
positive direct Coombs’ test Mat education (per year)
G6PD deficiency. Reference standard: OR: 0.8 (95% CI 0.7 to 0.9)
Hyperbilirubinaemia defined as
TSB Maternal blood type O
> 171 micromol/litre at day 2 OR: 2.9 (95% CI 1.5 to 5.8)
> 239 micromol/litre at day 3
> 291 micromol/litre at day 4–5 Full breastfeeding
OR: 0.4 (95% CI 0.2 to 0.9)
Analysis:
Association between various Day 1 TSB > 85 micromol/litre
factors and jaundice calculated OR: 36.5 (95% CI 15.9 to 83.6)
from multiple regression analysis

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