Page 134 - Screening for Cervical Cancer: Systematic Evidence Review

Appendix C. Evidence Tables

Evidence Table 2. New Methods for Preparing or Evaluating Cervical Cytology (cont'd)

Source: Study Design &
Author, Year Characteristics Interventions Location & Time Period
ThinPrep 2000
Inhorn et al., Diagnostic test evaluation ThinPrep vs. conventional 5 institutions, gynecologic
1998 106 of ThinPrep vs. Pap. oncology clinics
conventional Pap Split-sample, obtained with
broom device
Cancer specimens from
ThinPrep clinical trial,
including results from
ThinPrep beta and
ThinPrep 2000
ThinPrep and conventional
smear obtained from known
cancer patients, split-
sample

No disease negatives
studied

Papillo et al., Diagnostic test evaluation ThinPrep vs. conventional Vermont
1998 107 smear
ThinPrep slides compared 1997
with historical cohort of ThinPrep Direct to vial
conventional Pap slides for 12 practice sites that chose to
specimen adequacy and offer ThinPrep
yield of abnormal
diagnoses

Histologic verification of
most ThinPrep HSIL. No
verification of test-negatives

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