Page 35 - 78 glossary of hivaids-related terms_opt

Core
The inner protective coat of protein that surrounds the genetic
material of most viruses. In HIV, the core is mostly made up of the
p24 protein, which surrounds two copies of HIV’s genetic material. C

Coreceptor
A protein on the surface of a cell that serves as a second binding
site for a virus or other molecule. Although the CD4 protein is HIV’s
primary receptor, the virus must also bind to either the CCR5 or
CXCR4 coreceptor to get into a host cell.
See Also: CCR5
CXCR4
CD4 Receptor

CPCRA
See: Community Programs for Clinical Research on AIDS

Creatinine
A protein found in muscles and blood and excreted by the kidneys
into the urine. The level of creatinine in the blood or urine provides
a measure of kidney function. Increased levels of creatinine indicate
abnormal or impaired kidney function.

Cross Resistance
Cross resistance occurs when a micro-organism has changed,
or mutated, in such a way that it loses its susceptibility to multiple
drugs simultaneously. For example, HIV resistance to one NNRTI
drug usually produces resistance to the entire NNRTI drug class.
See Also: Drug Resistance
Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
Mutation

Cross Sensitivity
A drug reaction that may occur again with the use of a different, but
related, drug. Cross sensitivity can occur within a drug class, such
as when a person reacts to all NNRTIs similarly after treatment with

HIV/AIDS Glossary 33